2. Cytoskeleton NF-κB Immunology/Inflammation Apoptosis
  3. Integrin NF-κB Toll-like Receptor (TLR) TNF Receptor
  4. Mumefural

Mumefural 是 Prunus mume Sieb 加工果实中的一种生物活性成分。Mumefural 抑制血小板聚集。Mumefural 显示抗血栓作用，改善认知障碍。

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Mumefural Chemical Structure

Mumefural Chemical Structure

CAS No. : 222973-44-6

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Mumefural 相关抗体

Top Publications Citing Use of Products

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mumefural is a bioactive component of the processed fruit of Prunus mume Sieb. Mumefural inhibits platelet aggregation. Mumefural shows anti-thrombotic effects and ameliorates cognitive impairment[1][2].

IC50 & Target[1]

NF-κB

 

TLR4

 

P-selectin

 

E-selectin

 

TNF-α

 

体内研究
(In Vivo)

Mumefural (0.1-10 mg/kg; i.p.; once) 在大鼠中显示抗血栓作用[1]。
Mumefural (20-80 mg/kg; oral; daily for 42 days) 通过调节中隔海马胆碱能系统和神经炎症改善慢性脑灌注不足的认知障碍[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats, FeCl3-induced arterial thrombosis model[1]
Dosage: 0.1, 1, or 10 mg/kg
Administration: Intraperitoneal injection, 30 min before 35% FeCl3 treatment
Result: Significantly improved blood flow by inhibiting occlusion and thrombus formation. Prevented collagen fiber damage in injured vessels and inhibited the expression of the platelet activation-related proteins P-selectin and E-selectin. Significantly reduced the increased inflammatory signal of nuclear factor (NF)-κB, toll-like receptor 4 (TLR4), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 in blood vessels.
Animal Model: Male Wistar rats, Chronic cerebral hypoperfusion (CCH) model[2]
Dosage: 20, 40, or 80 mg/kg
Administration: Oral, once a day for 42 days
Result: Significantly improved cognitive impairment. Inhibited cholinergic system dysfunction, attenuated choline acetyltransferase-positive cholinergic neuron loss. Inhibited myelin basic protein degradation and increased the hippocampal expression of synaptic markers and cognition-related proteins. Reduced neuroinflammation, inhibited gliosis, and attenuated the activation of P2X7 receptor, TLR4/MyD88, NLRP3, and NF-κB.
Animal Model: SD rats[1]
Dosage: 2 or 10 mg/kg
Administration: IV or PO (Pharmacokinetic Analysis)
Result: Plasma pharmacokinetic parameters of Mumefural in SD rats[1]
T1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-t (ng⋅h/mL) F (%)
IV (2 mg/kg) 0.14±0.05 0.08±0 1894.54±580.66 564.73±178.35 -
PO (2 mg/kg) 0.69±0.69 0.31±0.13 1731.61±290.64 1043.28±202.37 36.95±7.17

AUC(0–t): area under the curve from the time of dosing to infinity; Cmax: maximum concentration; F: bioavailability; T1/2: terminal half-life; Tmax: time of the maximum concentration; SD: standard deviation; F was calculated using the following formula
分子量

300.22

Formula

C12H12O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mumefural 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mumefural222973-44-6IntegrinNF-κBToll-like Receptor (TLR)TNF ReceptorNuclear factor-κBNuclear factor-kappaBTumor Necrosis Factor ReceptorTNFRanti-thromboticSD ratsP-selectinE-selectinTLR4TNF-αIL-6Inhibitorinhibitorinhibit

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目录号：
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