2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. Mycothiazole

Mycothiazole 是线粒体电子传递链 (ETC) 复合物 I 的抑制剂。Mycothiazool 在癌细胞 Huh7 (IC50 为 55.8 μM) U87 和 MCF7 中表现出细胞毒性。Mycothiazole 在 Huh7 中诱导细胞凋亡 (apoptosis)。Mycothiazole 通过调节未折叠蛋白反应 (UPR) 和热休克反应 (HSR) 相关的转录因子 ATFS-1 和 HSF1，延长 C. elegans 的寿命。

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Mycothiazole Chemical Structure

Mycothiazole Chemical Structure

CAS No. : 114582-75-1

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Mycothiazole 相关抗体

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  • 生物活性

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生物活性

Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC50 is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans[1].

分子量

404.57

Formula

C22H32N2O3S
CAS 号
结构分类
初始来源

marine sponge
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mycothiazole 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Mycothiazole114582-75-1Mitochondrial MetabolismC. eleganshepatocellular carcinomaglioblastomabreast cancerMCF7Huh7U87BJHEK293Inhibitorinhibitorinhibit

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