2. Apoptosis
  3. Bcl-2 Family
  4. Navitoclax dihydrochloride

Navitoclax dihydrochloride  (Synonyms: ABT-263 dihydrochloride)

目录号: HY-10087A1
产品使用指南 技术支持

Navitoclax (ABT-263) dihydrochloride 是一种口服有效的 Bcl-2 抑制剂，可与 Bcl-xL，Bcl-2，Bcl-w 等多种 Bcl-2 家族蛋白结合，Ki 值小于 1 nM。Navitoclax dihydrochloride 可用于癌症领域的研究。

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Navitoclax dihydrochloride Chemical Structure

Navitoclax dihydrochloride Chemical Structure

CAS No. : 1093851-28-5

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Navitoclax dihydrochloride 的其他形式现货产品:

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Navitoclax dihydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 100 篇科研文献

Proliferation Assay
WB
RT-PCR
Cell Viability Assay

    Navitoclax dihydrochloride purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2024 Sep 6;43(1):253.  [Abstract]

    The co-treatment with ABT-263 (Navitoclax) (0.2 μM) and KRIBB-11 inhibits the cell viability in iCCA hCAFs. Effect of ABT-263, KRIBB-11, and their co-administration on the viability of iCCA hCAFs, grown for 72 h in culture medium supplemented with 10% FBS. Note the higher anti-growth effects of the two combined drugs than single treatments.

    Navitoclax dihydrochloride purchased from MCE. Usage Cited in: Nat Commun. 2022 Nov 10;13(1):6803.  [Abstract]

    Navitoclax (0.5-1.5 μM;10 d) combined with decitabine significantly reduces the transcriptional activity of KIAA1522-a6 in siPTBP1-transfected A2780 cells.

    Navitoclax dihydrochloride purchased from MCE. Usage Cited in: Cell Discov. 2022 Oct 6;8(1):102.  [Abstract]

    Cell viability of the captured clones in response to ABT263 (Navitoclax) (2 days). Results are representative of two independent experiments with three technical replicates per experiment, and error bars represent SEM.

    Navitoclax dihydrochloride purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Sep 24;9(10):986.  [Abstract]

    Cells are treated with 25 nM siRNA for 48 hours followed by 1 μM ABT-263 for 36 hours.

    Navitoclax dihydrochloride purchased from MCE. Usage Cited in: ACS Med Chem Lett. 2015 Jun 22;6(8):948-52.  [Abstract]

    Combination treatment. (a) Comparison of AZD-8055 and ABT-263 treatment in all cell lines. Red indicates sensitivity, while blue indicates resistance. (b) Depiction of synergism where the values shown are excess over Bliss Independence, a prediction of inhibition without synergism. Increased synergism is evident by an increased number, shown in red, while negative numbers in blue represent an antagonistic effect.

    查看 Bcl-2 Family 亚型特异性产品:

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    Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Navitoclax (ABT-263) dihydrochloride is an orally active Bcl-2 inhibitor that binds to various Bcl-2 family proteins, including Bcl-xL, Bcl-2, and Bcl-w, with a Ki value of less than 1 nM. Navitoclax dihydrochloride can be used in cancer research[1].

    分子量

    1047.53

    同用名

    ABT-263 dihydrochloride

    Formula

    C47H57Cl3F3N5O6S3
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Navitoclax dihydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Navitoclax1093851-28-5ABT-263ABT263ABT 263Bcl-2 FamilyInhibitorinhibitorinhibit

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