2. Apoptosis
  3. Bcl-2 Family
  4. Navitoclax dihydrochloride

Navitoclax dihydrochloride  (Synonyms: ABT-263 dihydrochloride)

目录号: HY-10087A1
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摩尔计算器

Navitoclax (ABT-263) dihydrochloride 是一种口服有效的 Bcl-2 抑制剂，可与 Bcl-xL，Bcl-2，Bcl-w 等多种 Bcl-2 家族蛋白结合，Ki 值小于 1 nM。Navitoclax dihydrochloride 可用于癌症领域的研究。

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Navitoclax dihydrochloride Chemical Structure

Navitoclax dihydrochloride Chemical Structure

CAS No. : 1093851-28-5

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Navitoclax dihydrochloride 的其他形式现货产品:

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Navitoclax dihydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 84 篇科研文献

Proliferation Assay
WB

    Navitoclax dihydrochloride purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Sep 24;9(10):986.  [Abstract]

    Cells are treated with 25 nM siRNA for 48 hours followed by 1 μM ABT-263 for 36 hours.

    Navitoclax dihydrochloride purchased from MCE. Usage Cited in: ACS Med Chem Lett. 2015 Jun 22;6(8):948-52.  [Abstract]

    Combination treatment. (a) Comparison of AZD-8055 and ABT-263 treatment in all cell lines. Red indicates sensitivity, while blue indicates resistance. (b) Depiction of synergism where the values shown are excess over Bliss Independence, a prediction of inhibition without synergism. Increased synergism is evident by an increased number, shown in red, while negative numbers in blue represent an antagonistic effect.

    查看 Bcl-2 Family 亚型特异性产品:

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    Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Navitoclax (ABT-263) dihydrochloride is an orally active Bcl-2 inhibitor that binds to various Bcl-2 family proteins, including Bcl-xL, Bcl-2, and Bcl-w, with a Ki value of less than 1 nM. Navitoclax dihydrochloride can be used in cancer research[1].

    分子量

    1047.53

    Formula

    C47H57Cl3F3N5O6S3
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Navitoclax dihydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

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    The dilution calculator equation

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    × = ×
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Navitoclax1093851-28-5ABT-263ABT263ABT 263Bcl-2 FamilyInhibitorinhibitorinhibit

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