2. Anti-infection
  3. Antibiotic Bacterial
  4. Nemonoxacin

Nemonoxacin  (Synonyms: TG-873870)

目录号: HY-14956 纯度: 99.80%
COA 产品使用指南

摩尔计算器

Nemonoxacin (TG-873870) 是一种口服有效的强效广谱抗生素。Nemonoxacin 对不同种类的葡萄球菌、链球菌和肠球菌、淋病奈瑟菌和流感嗜血杆菌均具有较好的抑制活性。Nemonoxacin 可用于细菌感染和社区获得性肺炎的研究。

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Nemonoxacin Chemical Structure

Nemonoxacin Chemical Structure

CAS No. : 378746-64-6

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规格 价格 是否有货 数量
1 mg ￥2200
In-stock
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Customer Review

Other Forms of Nemonoxacin:

Nemonoxacin 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nemonoxacin (TG-873870) is an orally active and potent broad-spectrum antibiotic. Nemonoxacin shows good inhibitory activity against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenza. Nemonoxacin can be used in the study of bacterial infections and community-acquired pneumonia[1][2][3].

IC50 & Target

Bacterial[1][2][3].
体外研究
(In Vitro)

Nemonoxacin (0-5.51 µM; 24 h) shows good antibacterial activity in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nemonoxacin 相关抗体:

Cell Viability Assay[1]

Cell Line: MSSA, MRSA
Concentration: 0-5.51 µM (0-2048 µg/mL)
Incubation Time: 24 h
Result: Inhibited MSSA and MRSA with MIC90 values of 0.12 and 4 µg/mL.
体内研究
(In Vivo)

Nemonoxacin (p.o.; 15 min and 6 h after infection) shows potent and broad-spectrum in vivo activity against both Gram-positive (S. aureus, S. capitis, S. pneumonia and E. faecalis) and Gram-negative (E. coli) isolates[2].
Nemonoxacin (p.o.; 6, 12 and 24 h after infection) shows potent activities towards (2.5, 5, 10, 20 mg/kg) S. pneumonia 0613 (PRSP) and (10, 20, 40, 80 mg/kg) K. pneumonia 0607 infections in mouse pulmonary infection model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 ICR mice (18-22 g; mouse systemic infection model)[2].
Dosage: 1.6-4.0 mg/kg (S. aureus and S. capitis infections), 2.4-10.0 mg/kg (S. pneumonia infections), 5.0-22.6 mg/kg (E. faecalis infections), 1.6-10.0 mg/kg (E. coli infections)
Administration: Oral administration; 15 min and 6 h after infection
Result: Showed the ED50s of 2.08, 2.59 and 2.52 mg/kg to against S. aureus ATCC 29213 (MSSA), S. aureus 0705 (MRSA) and S. capitis 0687 (levofloxacin-resistant MRSC), respectively.
Animal Model: CD-1 ICR mice (18-22 g; mouse pulmonary infection model)[2].
Dosage: 2.5, 5, 10, 20 mg/kg (S. pneumonia 0613 (PRSP)); 10, 20, 40, 80 mg/kg (K. pneumonia 0607)
Administration: Oral administration; 6, 12 and 24 h after infection
Result: Significantly decreased colony counts in vivo.
Clinical Trial
分子量

371.43

Formula

C20H25N3O4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 2 mg/mL (5.38 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6923 mL 13.4615 mL 26.9230 mL
5 mM 0.5385 mL 2.6923 mL 5.3846 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.80%

COA (263 KB) HNMR (151 KB) LCMS (97 KB)

产品使用指南 (1538 KB)
参考文献

Nemonoxacin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6923 mL 13.4615 mL 26.9230 mL 67.3074 mL
5 mM 0.5385 mL 2.6923 mL 5.3846 mL 13.4615 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nemonoxacin378746-64-6TG-873870TG873870TG 873870AntibioticBacterialCAPMSSAMRSAS. aureusbacterialcommunity-acquired pneumoniastaphylococcistreptococcienterococciInhibitorinhibitorinhibit

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