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  4. NU-8165

NU-8165是一种MDM2-p53蛋白-蛋白相互作用抑制剂，具有抗肿瘤活性。NU-8165的优化受MDM2 NMR滴定的指导，表明了关键的结合相互作用区域。NU-8165在细胞实验中激活MDM2和p21转录，并对野生型p53细胞系显示出适度的选择性。

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NU-8165 Chemical Structure

NU-8165 Chemical Structure

CAS No. : 849723-20-2

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NU-8165 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NU-8165 is an inhibitor of the MDM2-p53 protein-protein interaction with anti-tumor activity. Optimization of NU-8165 was guided by MDM2 NMR titrations, which indicated key binding interaction regions. NU-8165 activated MDM2 and p21 transcription in cell-based assays and showed modest selectivity for wild-type p53 cell lines[1].

分子量

407.89

Formula

C24H22ClNO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NU-8165 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NU-8165849723-20-2NU8165NU 8165OthersInhibitorinhibitorinhibit

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