2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Nucleoside Antimetabolite/Analog Endogenous Metabolite
  4. Orotic acid zinc

Orotic acid zinc  (Synonyms: 6-Carboxyuracil zinc; Vitamin B13 zinc)

目录号: HY-N0157A 纯度: 99.84%
COA 产品使用指南

摩尔计算器

Orotic acid (zinc)，一种嘧啶核苷酸和 RNA 生物合成的前体，从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放，通过细胞质 UMP 合酶转化为 UMP。Orotic acid (zinc) 是尿素循环异常的常规新生儿筛查中的测量指标。Orotic acid (zinc) 可引起大鼠肝脂肪变性和肝肿大。

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Orotic acid zinc Chemical Structure

Orotic acid zinc Chemical Structure

CAS No. : 68399-76-8

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100 mg ￥400
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500 mg ￥837
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Customer Review

Other Forms of Orotic acid zinc:

Orotic acid zinc 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Orotic acid is found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Orotic acid zinc 相关抗体:
体内研究
(In Vivo)

Orotic acid is a marker for measurement of urea cycle disorders (UCDs), including ornithine transcarbamylase deficiency (OTCD)[2].
Orotic acid (1.0% addition to the diet; p.o. for 3-10 d) induces a development of fatty liver by day 7, and decreases purine/pyrimidine ratio of hepatic acid-soluble nucleotides by day 3[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

188.79

Formula

C5H4N2O4Zn0.5
CAS 号
性状

固体

颜色

White to off-white

中文名称

乳清酸锌；乳清酸锌二水合物
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 20 mg/mL (105.94 mM; ultrasonic and adjust pH to 2 with 1 M HCL; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.2969 mL 26.4845 mL 52.9689 mL
5 mM 1.0594 mL 5.2969 mL 10.5938 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Orotic acid zinc 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.2969 mL 26.4845 mL 52.9689 mL 132.4223 mL
5 mM 1.0594 mL 5.2969 mL 10.5938 mL 26.4845 mL
10 mM 0.5297 mL 2.6484 mL 5.2969 mL 13.2422 mL
15 mM 0.3531 mL 1.7656 mL 3.5313 mL 8.8282 mL
20 mM 0.2648 mL 1.3242 mL 2.6484 mL 6.6211 mL
25 mM 0.2119 mL 1.0594 mL 2.1188 mL 5.2969 mL
30 mM 0.1766 mL 0.8828 mL 1.7656 mL 4.4141 mL
40 mM 0.1324 mL 0.6621 mL 1.3242 mL 3.3106 mL
50 mM 0.1059 mL 0.5297 mL 1.0594 mL 2.6484 mL
60 mM 0.0883 mL 0.4414 mL 0.8828 mL 2.2070 mL
80 mM 0.0662 mL 0.3311 mL 0.6621 mL 1.6553 mL
100 mM 0.0530 mL 0.2648 mL 0.5297 mL 1.3242 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orotic acid68399-76-86-CarboxyuracilVitamin B13乳清酸锌乳清酸锌二水合物Vitamin B 13Vitamin B-13Nucleoside Antimetabolite/AnalogEndogenous MetabolitepyrimidinenucleotidesRNAureahepaticsteatosishepatomegalyInhibitorinhibitorinhibit

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