2. Anti-infection
  3. Influenza Virus
  4. PAN endonuclease-IN-1

PAN endonuclease-IN-1 (Compound 23) 是有效的 PAN 内切酶的抑制剂，其对 WT、I38T 和 E23K PAN 内切酶的 Kd 值分别为 277 μM、384 μM 和 328 μM。RNA 依赖性的 RNA 聚合酶 N 端内切酶是流感病毒复制机制的关键组成部分，是抗病毒靶点。

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PAN endonuclease-IN-1 Chemical Structure

PAN endonuclease-IN-1 Chemical Structure

CAS No. : 2378640-67-4

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PAN endonuclease-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with Kd values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target[1].

IC50 & Target

Kd: 277 μM, 384 μM and 328 μM for WT, I38T and E23K PAN endonucleases[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MDCK CC50
> 800 μM
Compound: 23
Cytotoxicity in MDCK cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay
Cytotoxicity in MDCK cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay
[PMID: 31536340]
NIH3T3 CC50
> 800 μM
Compound: 23
Cytotoxicity in mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay
Cytotoxicity in mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 12 hrs by MTT assay
[PMID: 31536340]
分子量

367.24

Formula

C14H8F3N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PAN endonuclease-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAN endonuclease-IN-12378640-67-4Influenza Virusinfluenzaviral replicationantiviralInhibitorinhibitorinhibit

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