Panobinostat-d₄ (Synonyms: LBH589-d₄; NVP-LBH589-d₄)

目录号: HY-10224S: FAQs
Data Sheet 产品使用指南

摩尔计算器

Panobinostat-d₄ 是 Panobinostat 的氘代物。Panobinostat (LBH589; NVP-LBH589) 是一种有效的口服非选择性 HDAC 抑制剂，具有抗肿瘤活性。Panobinostat 可诱导 HIV-1 virus 的产生，即使在较低的浓度范围 8-31 nM，也可刺激 HIV-1 在潜伏感染细胞中的表达。Panobinostat 诱导细胞凋亡 (apoptosis) 和自噬 (autopha

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Panobinostat-d₄ Chemical Structure

CAS No. : 1185237-51-7

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Panobinostat-d₄ hydrochloride 询价

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Panobinostat-d₄ 相关抗体

Panobinostat-d₄ 相关产品

•同靶点产品:

•同靶点蛋白产品:

查看 HDAC 亚型特异性产品:

查看所有亚型

HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 HIV 亚型特异性产品:

查看所有亚型

HIV HIV-1 HIV-2

生物活性

纯度 & 产品资料

参考文献

生物活性

Panobinostat-d₄ is the deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Panobinostat-d₄ 相关抗体:

分子量

353.45

Formula
C₂₁H₁₉D₄N₃O₂

CAS 号
1185237-51-7

非标记 CAS
404950-80-7

中文名称
帕比司他 d₄

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

Data Sheet (533 KB) 产品使用指南 (1538 KB)

参考文献

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Scuto A, et al. The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Blood. 2008 May 15;111(10):5093-100. [Content Brief]

[3]. Crisanti MC, et al. The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer. Mol Cancer Ther. 2009 Aug;8(8):2221-31. [Content Brief]

[4]. Ocio EM, et al. In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma. Haematologica. 2010 May;95(5):794-803. [Content Brief]

[5]. Banerjee NS, et al. Vorinostat, a pan-HDAC inhibitor, abrogates productive HPV-18 DNA amplification. Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11138-E11147. [Content Brief]

[6]. Barton K, et al. Broad activation of latent HIV-1 in vivo. Nat Commun. 2016;7:12731. Published 2016 Sep 8. [Content Brief]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Scuto A, et al. The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Blood. 2008 May 15;111(10):5093-100.

[3]. Crisanti MC, et al. The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer. Mol Cancer Ther. 2009 Aug;8(8):2221-31.

[4]. Ocio EM, et al. In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma. Haematologica. 2010 May;95(5):794-803.

[5]. Banerjee NS, et al. Vorinostat, a pan-HDAC inhibitor, abrogates productive HPV-18 DNA amplification. Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11138-E11147.

[6]. Barton K, et al. Broad activation of latent HIV-1 in vivo. Nat Commun. 2016;7:12731. Published 2016 Sep 8.

Panobinostat-d₄ 相关分类

同位素标记物

科研领域用同位素标记物临床质谱同位素内标品同位素标记抑制剂氘（²H， D）

同位素标记抑制剂体内实验中应用较多的稳定同位素标记抑制剂药物浓度检测

Cancer

肿瘤靶向治疗肿瘤免疫肿瘤代谢与转移

Cell Cycle/DNA Damage Epigenetics Autophagy Anti-infection Apoptosis

HDAC Autophagy HIV Apoptosis

摩尔计算器

稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量浓度体积分子量 *

= × ×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start) × 体积 _(start) = 浓度 _(final) × 体积 _(final)

× = ×

C1 V1 C2 V2

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Keywords:

Panobinostat-d₄1185237-51-7LBH589-d₄NVP-LBH589-d₄帕比司他 d₄HDACAutophagyHIVApoptosisHistone deacetylasesHuman immunodeficiency virusInhibitorinhibitorinhibit

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生物活性	Panobinostat-d₄ is the deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Panobinostat-d₄ 相关抗体:
分子量	353.45
Formula	C₂₁H₁₉D₄N₃O₂
CAS 号	1185237-51-7
非标记 CAS	404950-80-7
中文名称	帕比司他 d₄
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料	Data Sheet (533 KB) 产品使用指南 (1538 KB)
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief] [2]. Scuto A, et al. The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Blood. 2008 May 15;111(10):5093-100. [Content Brief] [3]. Crisanti MC, et al. The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer. Mol Cancer Ther. 2009 Aug;8(8):2221-31. [Content Brief] [4]. Ocio EM, et al. In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma. Haematologica. 2010 May;95(5):794-803. [Content Brief] [5]. Banerjee NS, et al. Vorinostat, a pan-HDAC inhibitor, abrogates productive HPV-18 DNA amplification. Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11138-E11147. [Content Brief] [6]. Barton K, et al. Broad activation of latent HIV-1 in vivo. Nat Commun. 2016;7:12731. Published 2016 Sep 8. [Content Brief]

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Panobinostat-d₄ (Synonyms: LBH589-d₄; NVP-LBH589-d₄)

Customer Review

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Panobinostat-d₄ 相关产品

•同靶点产品:

•同靶点蛋白产品:

查看 HDAC 亚型特异性产品:

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生物活性

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参考文献

Panobinostat-d₄ 相关分类

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Panobinostat-d4 (Synonyms: LBH589-d4; NVP-LBH589-d4)

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Panobinostat-d4 相关抗体

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Panobinostat-d₄ (Synonyms: LBH589-d₄; NVP-LBH589-d₄)

Other Forms of Panobinostat-d₄:

Panobinostat-d₄ 相关抗体

Panobinostat-d₄ 相关产品

Panobinostat-d₄ 相关抗体:

Panobinostat-d₄ 相关分类