2. Antibody-drug Conjugate/ADC Related
  3. Antibody-Drug Conjugates (ADCs)
  4. Patritumab deruxtecan

Patritumab deruxtecan  (Synonyms: HER3-DXd; U3-1402)

目录号: HY-P99813 纯度: 99.08%
COA

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Patritumab deruxtecan (HER3-DXd) 是一种抗体-活性分子偶联物 (ADC)，由全人抗 HER3 IgG1 单克隆抗体 Patritumab (HY-P99275) 通过基于四肽的可裂解接头连接到拓扑异构酶 I 抑制剂有效载荷组成 [1]。

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Patritumab deruxtecan Chemical Structure

Patritumab deruxtecan Chemical Structure

CAS No. : 2227102-46-5

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规格 价格 是否有货 数量
1 mg ￥7500
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Patritumab deruxtecan 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity[1].

体外研究
(In Vitro)

Patritumab deruxtecan 对表达 HER3 突变的乳腺癌细胞表现出活性，无论HER2是否过表达[1]。
Patritumab deruxtecan (0-100 nM) 以浓度依赖性方式结合所有 HER3 突变体和 HER3WT MDA-MB-231 细胞的表面，但不结合 HER3< sup>EV 细胞[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Patritumab deruxtecan 相关抗体:
Clinical Trial
分子量

158000 (average)

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.08%

COA (266 KB) Others (486 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Patritumab deruxtecan 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Patritumab deruxtecan2227102-46-5HER3-DXd U3-1402Antibody-Drug Conjugates (ADCs)Antibody-Drug Conjugatesbreast cancerMDA-MB-231 cellsInhibitorinhibitorinhibit

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