2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Apoptosis Autophagy
  3. Dopamine Receptor Histamine Receptor 5-HT Receptor Adrenergic Receptor Apoptosis Autophagy
  4. Perphenazine dihydrochloride

Perphenazine dihydrochloride  (Synonyms: 奋乃静二盐酸盐；过非那嗪二盐酸盐；羟哌氯丙嗪二盐酸盐；丕芬那辛二盐酸盐)

目录号: HY-A0077A
产品使用指南

摩尔计算器

Perphenazine dihydrochloride 是一种具有口服活性的多巴胺受体 (dopamine receptor) 和组胺-1 受体 (histamine-1 receptor) 拮抗剂, Ki 值分别为 0.56 nM (D2)、0.43 nM (D3)、0.6 nM (5-HT2A)。Perphenazine dihydrochloride 还可与 Alpha-1A 肾上腺素受体 (Alpha-1A adrenergic receptor) 结合。Perphenazine dihydrochloride 抑制癌细胞增殖，并诱导细胞凋亡 (apoptosis)。Perphenazine dihydrochloride 可用于精神疾病、癌症、炎症的研究。

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Perphenazine dihydrochloride Chemical Structure

Perphenazine dihydrochloride Chemical Structure

CAS No. : 2015-28-3

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Perphenazine dihydrochloride 的其他形式现货产品:

Customer Review

Other Forms of Perphenazine dihydrochloride:

Perphenazine dihydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Perphenazine dihydrochloride is an orally active dopamine receptor and histamine-1 receptor antagonist, with Ki values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine dihydrochloride also binds to Alpha-1A adrenergic receptor. Perphenazine dihydrochloride inhibits cancer cell proliferation, and induces apoptosis. Perphenazine dihydrochloride can be used in the research of mental disease, cancer, inflammation[1][3][5].

IC50 & Target[1]

D2 Receptor

0.56 nM (Ki)

D3 Receptor

0.43 nM (Ki)

D4 Receptor

28.5 nM (Ki)

5-HT2A Receptor

5.6 nM (Ki)

5-HT6 Receptor

17 nM (Ki)

5-HT7 Receptor

23 nM (Ki)

5-HT2C Receptor

132 nM (Ki)

5-HT1A Receptor

421 nM (Ki)

体外研究
(In Vitro)

Perphenazine (40 μM, 48 h) dihydrochloride inhibits cell viability, and induces cell apoptosis mediated by CTSD (Cathepsin D) in L02 cells[2].
Perphenazine (30 μM, 24 h) dihydrochloride induces intense lysosome vacuolation, impaired lysosomal membrane, and induces lysosomal membrane permeabilization (LMP), ultimately triggering lysosomal cell death in L02 cells[2].
Perphenazine (10-40 μM, 24 h) dihydrochloride inhibits autophagic flux in L02 cells[2].
Perphenazine (1 µM, 24 h) dihydrochloride decreases glioblastoma U-87 MG cell migration and invasion[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Perphenazine dihydrochloride 相关抗体:

Cell Viability Assay[2]

Cell Line: L02 cells
Concentration: 10-100 μM
Incubation Time: 12, 24, 48 h
Result: Inhibited cell viability in a concentration and time-dependent manner.

Western Blot Analysis[2]

Cell Line: L02 cells
Concentration: 10, 20, 30, and 40 μM
Incubation Time: 24 h
Result: Increased LC3 I/II and P62/SQSTM1 levels

Cell Migration Assay [4]

Cell Line: U-87 MG cells
Concentration: 0, 3, 6, 9, 12, and 24 h
Incubation Time: 0, 3, 6, 9, 12, and 24 h
Result: Increased the wound closure in human glioblastoma cell cultures from 24.6 to 62.7%.
体内研究
(In Vivo)

Perphenazine (oral gavage, 180 mg/kg, every other day for 21 days) dihydrochloride induces liver injury and lysosomal membrane damage in ICR mice[2].
Perphenazine (oral administration, 10 mg/kg, every other day for 6 days) dihydrochloride attenuates morphological phenotype in mouse models of Th2-type allergic dermatitis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice[2]
Dosage: 10, 30, 60, 120, 180 mg/kg
Administration: Oral gavage, every other day for 21 days.
Result: Increased histological injury and aminotransferases compared with control.
Animal Model: Oxazolone-treated animal model of dermatitis[3]
Dosage: 10 mg/kg
Administration: Oral administration, every other day for 6 days
Result: Decreased The levels of mice ear swelling.
Clinical Trial
分子量

476.89

Formula

C21H28Cl3N3OS
CAS 号
中文名称

奋乃静二盐酸盐；过非那嗪二盐酸盐；羟哌氯丙嗪二盐酸盐；丕芬那辛二盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Perphenazine dihydrochloride 相关分类

  • 摩尔计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Perphenazine2015-28-3奋乃静二盐酸盐过非那嗪二盐酸盐羟哌氯丙嗪二盐酸盐丕芬那辛二盐酸盐Dopamine ReceptorHistamine Receptor5-HT ReceptorAdrenergic ReceptorApoptosisAutophagySerotonin Receptor5-hydroxytryptamine ReceptorBeta ReceptorMental diseaseliver injuryhepatotoxicitydermatitisinflammationU-87 MG cellsanti-cancerlysosomeInhibitorinhibitorinhibit

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