2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. (+)-Niguldipine hydrochloride

(+)-Niguldipine hydrochloride  (Synonyms: (S)-Niguldipine hydrochloride)

目录号: HY-101390 纯度: 98.06%
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摩尔计算器

(+)-Niguldipine hydrochloride 是一种钙通道拮抗剂。(+)-Niguldipine hydrochloride 通过阻断钙通道，减少钙离子的跨膜内流，发挥血管舒张作用。(+)-Niguldipine hydrochloride 可抑制 U-46619 (HY-108566) 诱发的豚鼠 Langendorff 心脏冠状动脉收缩 (pID50 为 11.37)，对豚鼠骨骼肌膜上的钙通道结合位点有高亲和性 (Ki 为 9.75)，降低自发性高血压大鼠的血压 (pED30 为 7.1)。(+)-Niguldipine hydrochloride 可改善高血压、心绞痛、心律失常等心血管疾病。

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(+)-Niguldipine hydrochloride Chemical Structure

(+)-Niguldipine hydrochloride Chemical Structure

CAS No. : 113145-69-0

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规格 价格 是否有货 数量
1 mg ￥1800
In-stock
5 mg ￥4470
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Other Forms of (+)-Niguldipine hydrochloride:

(+)-Niguldipine hydrochloride 相关抗体

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(+)-Niguldipine hydrochloride is an antagonist for calcium channel. (+)-Niguldipine hydrochloride produces vasodilation by blocking calcium channels and reducing the transmembrane influx of calcium ions. (+)-Niguldipine hydrochloride inhibits U-46619 (HY-108566)-induced coronary vasoconstriction in guinea pig Langendorff heart with pID50 of 11.37, binds to calcium channel on guinea pig skeletal muscle membrane with Ki of 9.75, and lowers the blood pressure in spontaneously hypertensive rat with pED30 of 7.1. (+)-Niguldipine hydrochloride ameliorates cardiovascular diseases such as hypertension, angina pectoris and arrhythmias[1].

分子量

646.17

Formula

C36H40ClN3O6
CAS 号
性状

固体

颜色

Off-white to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

(+)-Niguldipine hydrochloride 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Niguldipine113145-69-0(S)-NiguldipineCalcium ChannelCa2+ channelsCa channelsguinea pighypertensionangina pectorisarrhythmiasInhibitorinhibitorinhibit

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目录号：
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