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  4. Polyketide synthase 13-IN-3

Polyketide synthase 13-IN-3 (compound 41) 是聚酮合酶13 (polyketide synthase 13) 抑制剂，其对 M. tuberculosis H37Rv 属的MIC 值为0.0625-0.125 μg/mL。

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Polyketide synthase 13-IN-3 Chemical Structure

Polyketide synthase 13-IN-3 Chemical Structure

CAS No. : 2221801-50-7

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Polyketide synthase 13-IN-3 相关抗体

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生物活性

Polyketide synthase 13-IN-3 (compound 41) is a polyketide synthase 13 inhibitor，with a MIC of 0.0625-0.125 μg/mL against the M. tuberculosis strain H37Rv[1].

IC50 & Target

MIC: 0.0625-0.125 μg/mL (M. tuberculosis strain H37Rv)[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
> 50 μg/mL
Compound: 41
Cytotoxicity against human HEK293 cells after 48 hrs by CellTiter96 AQueous one solution assay
Cytotoxicity against human HEK293 cells after 48 hrs by CellTiter96 AQueous one solution assay
[PMID: 29328655]
HFL1 IC50
> 50 μg/mL
Compound: 41
Cytotoxicity against HFL1 cells after 48 hrs by CellTiter96 AQueous one solution assay
Cytotoxicity against HFL1 cells after 48 hrs by CellTiter96 AQueous one solution assay
[PMID: 29328655]
MRC5 IC50
> 50 μg/mL
Compound: 41
Cytotoxicity against human MRC5 cells after 48 hrs by CellTiter96 AQueous one solution assay
Cytotoxicity against human MRC5 cells after 48 hrs by CellTiter96 AQueous one solution assay
[PMID: 29328655]
Vero IC50
4 μg/mL
Compound: 41
Cytotoxicity against African green monkey Vero cells after 72 hrs by MABA
Cytotoxicity against African green monkey Vero cells after 72 hrs by MABA
[PMID: 29328655]
分子量

349.38

Formula

C21H19NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Polyketide synthase 13-IN-3 相关分类

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Keywords:

Polyketide synthase 13-IN-32221801-50-7OthersTuberculosisTBPolyketideSynthaseInhibitorinhibitorinhibit

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