2. Anti-infection Antibody-drug Conjugate/ADC Related
  3. Bacterial ADC Cytotoxin Parasite
  4. Polyketomycin

Polyketomycin 是一种从链霉菌属中分离的四环醌糖苷抗生素。Polyketomycin 抑制革兰氏阳性细菌 (Gram-positive bacteria) 的生长，其 MIC 值小于 0.2 µg/mL。Polyketomycin 具有抗菌，抗癌，抗疟疾的作用。

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Polyketomycin Chemical Structure

Polyketomycin Chemical Structure

CAS No. : 200625-47-4

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Polyketomycin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3].

IC50 & Target[1][2]

Plasmodium

 

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

Polyketomycin exhibits growth inhibition against L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adnocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma and B16-BL10 melanoma with IC50 values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL and 1.6 μg/mL, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Polyketomycin 相关抗体:
体内研究
(In Vivo)

The acute toxicity (LD50, ip) of Polyketomycin in mice is estimated to be 6.25-12.5mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

864.84

Formula

C44H48O18
CAS 号
结构分类
初始来源

Streptomyces sp. MK277-AF1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Polyketomycin 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Polyketomycin200625-47-4BacterialADC CytotoxinParasiteADC PayloadADCCytotoxinMRSAantibioticanticancertetracyclicquinoneglycosideantimalarialInhibitorinhibitorinhibit

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