2. 重组蛋白
  3. Fc Receptors
  4. Fc Receptor-like Proteins
  5. Fc Receptor Like 1 (FCRL1)

Fc Receptor Like 1 (FCRL1)  

重组蛋白定制服务

FCRL molecules belong to the immunoglobulin super family (IgSF) with a potential activating and inhibitory roles. The FCRL genes encode two intracellular receptors (FCRL A and B) and six transmembrane glycoproteins type I (FCRL1-6). FCRL1-6 are all type 1 transmembrane glycoproteins that contain immunoglobulin-like domains in their extracellular regions. They consist of three to nine immunoglobulin (Ig)-like domains in the extracellular region and immunoreceptor tyrosine-based activation (ITAM)/inhibition (ITIM) motifs in their cytoplasmic domain. Unlike FcRs, which are typically either activatory or inhibitory, three of the FCRLs (FCRL2, FCRL3, and FCRL5) contain both activatory and inhibitory sequences, suggesting that they might be capable of dual-modulation. FCRL1-5 are dominantly expressed in different stages of B-cells development. But, FCRL6 is preferentially expressed in different subsets of T-cells and NK cells. FCRL1-5 could regulate different features of B-cell evolution such as development, differentiation, activation, antibody secretion and isotype switching.

目录号 产品名 / 同用名 种属 表达系统
  • HY-P72655
    FCRL1 Protein, Human (HEK293, His)

    Fc receptor-like protein 1; FcRL1; FcRH1; hIFGP1; CD307a; FCRH1; IFGP1; IRTA5

    		Human HEK293
    FCRL1 蛋白可能充当 B 细胞中的激活辅助受体，表明参与 B 细胞激活和分化过程。FCRL1 的双重作用使其成为调节 B 细胞反应和增强与 B 细胞激活相关的信号通路的关键角色。FCRL1 Protein, Human (HEK293, His) 是重组的 FCRL1 蛋白，由 HEK293 表达，带有 C-His 标签。
  • HY-P72656
    FCRL1 Protein, Mouse (203a.a, HEK293, His)

    Fc receptor-like protein 1; FcRL1; FcRH1; hIFGP1; CD307a; FCRH1; IFGP1; IRTA5

    		Mouse HEK293
    Fc受体样蛋白1 (Fcrl1) 是属于 FCRL 家族的细胞表面膜蛋白。Fcrl1 是 BCR 辅助受体，可增强通过 B 细胞受体的信号传导。Fcrl1 促进 B 细胞增殖和钙动员。Fcrl1 是一种生物标志物，也是 B 细胞淋巴增殖性疾病的重要靶点。FCRL1 Protein, Mouse (203a.a, HEK293, His) 是重组的 FCRL1 蛋白，由 HEK293 表达，带有 C-6*His 标签。
  • HY-P76923
    FCRL1 Protein, Mouse (Q8R4Y0-2, HEK293, His)

    Fc receptor-like protein 1; FcRL1; FcRH1; hIFGP1; CD307a; FCRH1; IFGP1; IRTA5

    		Mouse HEK293
    FCRL1 蛋白是 B 细胞中潜在的激活辅助受体，可能在 B 细胞激活和分化中发挥作用。尽管确切的机制正在研究中，但 FCRL1 的存在表明它参与了与 B 细胞功能和免疫反应相关的复杂信号通路。FCRL1 Protein, Mouse (Q8R4Y0-2, HEK293, His) 是重组的 FCRL1 蛋白，由 HEK293 表达，带有 C-His 标签。
目录号 产品名 作用方式 纯度
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