2. Antibody-drug Conjugate/ADC Related Anti-infection
  3. ADC Cytotoxin Bacterial
  4. Py-MPB-amino-C3-PBD

Py-MPB-amino-C3-PBD 是一种细胞毒性活性分子，可作为 ADC 的有效载荷。具有抗微生物活性。

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Py-MPB-amino-C3-PBD Chemical Structure

Py-MPB-amino-C3-PBD Chemical Structure

CAS No. : 2412924-07-1

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Py-MPB-amino-C3-PBD 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1].

IC50 & Target[1] [1] [1]

Pyrrolobenzodiazepines

 

体外研究
(In Vitro)

Py-MPB-amino-C3-PBD (compound 73) shows cytotoxicity with IC50s of 301, 144.1 and 37.5 nM for U138-MG, A431, and REH cells, respectively. Py-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12, with potency of 2 pg/mL determined[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Py-MPB-amino-C3-PBD 相关抗体:
分子量

744.84

Formula

C41H44N8O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Py-MPB-amino-C3-PBD 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Py-MPB-amino-C3-PBD2412924-07-1ADC CytotoxinBacterialADC PayloadDNApayloadcytotoxicityU138-MGA431REHcellsE. coliInhibitorinhibitorinhibit

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