ADH1B 蛋白, Human (His-SUMO)

ADH1B Protein, Human (His-SUMO) is an enzyme encoded by the ADH1B gene and is involved in the main ethanol metabolism pathway.

ADH1B（酒精脱氢酶 1B（I 类），β 多肽）基因及其最著名的功能等位基因 Arg48His（rs1229984，ADH1B*2）和 Arg370Cys（rs2066702，ADH1B*3）已被研究与许多表型性状的关系;最常见的包括酒精代谢和饮酒行为，还包括人类进化、肝功能、癌症，以及最近的综合人类现象。据报道，除乙醇外，ADH1B 还参与许多化合物的代谢途径，包括脂肪酸、丙酮、肾上腺素、葡萄糖、视黄醇、酪氨酸、色氨酸、异环磷酰胺、环磷酰胺、阿巴卡韦和塞来昔布；尤其是神经递质血清素和去甲肾上腺素^[1][2]。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

N-6*His;N-SUMO

P00325 (S2-F375)

125  [NCBI]

STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF

Approximately 55.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.

• [1]. Renato Polimanti, et al. ADH1B: From alcoholism, natural selection, and cancer to the human phenome. Am J Med Genet B Neuropsychiatr Genet. 2018 Mar;177(2):113-125.  [Content Brief]

  [2]. Liza D Morales, et al. Further evidence supporting a potential role for ADH1B in obesity. Sci Rep. 2021 Jan 21;11(1):1932.  [Content Brief]