Animal-Free I-TAC/CXCL11 蛋白, Mouse (His)

The CXCL11 protein selectively attracts interleukin-activated T cells and induces calcium release in these cells. Its binding to CXCR3 suggests a complex role in T cell chemotaxis and may be important in CNS diseases involving T cell recruitment. Animal-Free I-TAC/CXCL11 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeI-TAC/CXCL11 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free I-TAC/CXCL11 Protein, Mouse (His) is 79 a.a., with molecular weight of ~9.92 kDa.

CXCL11 蛋白对白细胞介素激活的 T 细胞表现出特定的趋化活性，但对未刺激的 T 细胞、中性粒细胞或单核细胞则没有。它能够在活化的 T 细胞中特异性诱导钙释放，这表明它在免疫反应中具有靶向作用。通过与 CXCR3 结合，CXCL11 复杂地参与 T 细胞趋化作用，表明其在涉及 T 细胞募集的中枢神经系统疾病中具有潜在意义。此外，根据其功能的相似性推断，CXCL11 可能有助于皮肤免疫反应。CXCL11 通过 Link 结构域与 TNFAIP6 相互作用表明其具有调节作用，强调其参与调节复杂细胞微环境中的趋化因子活性。

Measure by its ability to chemoattract BaF3 cells transfected with human CXCR3. The ED₅₀ for this effect is <10 ng/mL.

Mouse

E. coli

N-His

Q9JHH5 (F22-M100)

56066  [NCBI]

FLMFKQGRCLCIGPGMKAVKMAEIEKASVIYPSNGCDKVEVIVTMKAHKRQRCLDPRSKQARLIMQAIEKKNFLRRQNM

Approximately 9.92 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 7.4, trehalose or PBS, pH 7.4.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.