Annexin A5/ANXA5 蛋白, Human (solution)

Annexin A5 Protein, Human is a 35 kDa multifunctional protein which belongs to the annexin family. Annexin A5 induces in vitro fusion and aggregation of vesicles in a Ca²⁺- and acidic-pH-dependent manner.Annexin A5 is accepted as an early marker of apoptosis. Annexin A5 has anti-thrombotic and anti-microbial properties^[1].

膜联蛋白由一个蛋白质家族组成，参与细胞膜动力学的许多方面和膜相关蛋白的调节。
重组人膜联蛋白 A5 是一种 Ca²⁺ 敏感蛋白，与带负电的磷脂结合，与其他脂质微结构域建立特异性相互作用^[1]。
重组人膜联蛋白 A5 促进自噬体向溶酶体的递送并抑制内吞作用。膜联蛋白 A5 通过 Ca²⁺ 和磷脂信号通路可能成为自噬的正调节因子和内吞作用的负调节因子^[1][1] 。

Human

E. coli

Tag Free

P08758 (A2-D320)

308  [NCBI]

AQVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGEDD

Approximately 33.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filter solution of 20 mM Tris-HCl, 1 mM DTT, 10% Glycerol, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

• [1]. Guochang Hu, et al. Recombinant human annexin A5: a novel drug candidate for treatment of sepsis? Crit Care Med. 2014 Jan;42(1):219-20.  [Content Brief]

  [2]. Ghita Ghislat, et al. Annexin A5 stimulates autophagy and inhibits endocytosis. J Cell Sci. 2012 Jan 1;125(Pt 1):92-107.  [Content Brief]