B7-H6 蛋白, Human (Biotinylated, HEK293, His-Avi)

B7-H6, a distinctive monomeric protein, uniquely triggers NCR3-dependent natural killer (NK) cell activation, specifically interacting with NCR3 while avoiding engagement with other NK cell-activating receptors (NCR1, NCR2, and KLRK1). This specificity underscores B7-H6's unique role in initiating NK cell responses through the NCR3 pathway within the intricate network of NK cell activation mechanisms. B7-H6 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived B7-H6 protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of B7-H6 Protein, Human (Biotinylated, HEK293, His-Avi) is 238 a.a., with molecular weight of 48-65 kDa.

B7-H6 是一种独特的蛋白质，可作为 NCR3 依赖性自然杀伤 (NK) 细胞激活的触发因素。作为单体，B7-H6 表现出与 NCR3 的特异性相互作用，明显避免与其他 NK 细胞激活受体（例如 NCR1、NCR2 和 KLRK1）结合。这种相互作用凸显了其在通过 NCR3 途径启动 NK 细胞反应中的独特作用，展示了其在 NK 细胞激活机制的复杂网络中的特异性。

Human NKp30 hFc captured on CM5 Chip via Protein A can bind Biotinylated Human B7-H6 His-Avi with an affinity constant of 0.275 μM as determined in SPR assay.

Human

HEK293

C-His;C-Avi

Q68D85 (D25-S262)

374383  [NCBI]

48-65 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.