CD300a/LMIR1 蛋白, Cynomolgus (HEK293, His)

CD300a/LMIR1 Protein, an inhibitory receptor, potentially diminishes cytolytic activity in NK cells and suppresses mast cell degranulation. It serves as a negative regulator in MYD88-mediated TLR signaling, activating PTPN6 but not TRIF. Upon tyrosine phosphorylation, CD300a/LMIR1 engages with PTN6/SHP-1, PTPN11/SHP-2, and INPP5D, showcasing its multifaceted involvement in immune regulation and cellular responses. CD300a/LMIR1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD300a/LMIR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD300a/LMIR1 Protein, Cynomolgus (HEK293, His) is 161 a.a., with molecular weight of 45-50 kDa.

CD300a/LMIR1 是一种抑制性受体，可能在减少自然杀伤 (NK) 细胞的溶细胞活性和抑制肥大细胞脱粒方面发挥作用。此外，它通过激活 PTPN6，在 MYD88（尽管不是 TRIF）介导的 Toll 样受体 (TLR) 信号传导中充当负调节因子。酪氨酸磷酸化后，CD300a/LMIR1 与 PTN6/SHP-1 和 PTPN11/SHP-2 以及 INPP5D 结合，说明其在免疫调节和细胞反应中的多方面参与。

Cynomolgus

HEK293

C-His

A0A7N9CE79 (L18-Q178)

/

45-50 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.