1. 重组蛋白
  2. CD Antigens Fc Receptors
  3. Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins Fc-gamma Receptor
  4. Fc-gamma Receptor I/CD64
  5. CD64 蛋白, Human (CHO, C-His)

CD64 蛋白, Human (CHO, C-His)

目录号: HY-P72925
产品使用指南

CD64 蛋白是一种高亲和力受体,介导 IgG 效应器功能,触发抗体依赖性细胞毒性 (ADCC)。它与 IGHG1 相互作用,并与 FCERG1 形成信号复合物,有助于免疫反应。CD64 还与 FLNA、EPB41L2、LAT、PPL、HCK 和 LYN 相互作用,防止 FCGR1A 降解并调节免疫功能。CD64 蛋白, Human (CHO, C-His) 是重组的 CD64 蛋白,由 CHO 表达,带有 C-His 标签。

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SPR 检测服务   重组蛋白定制服务

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描述

CD64 protein, a high affinity receptor, mediates IgG effector functions, triggering antibody-dependent cellular cytotoxicity (ADCC). It interacts with IGHG1 and forms a signaling complex with FCERG1, contributing to immune responses. CD64 also interacts with FLNA, EPB41L2, LAT, PPL, HCK, and LYN to prevent degradation of FCGR1A and regulate immune function. CD64 Protein, Human (CHO, C-His) is the recombinant human-derived CD64 protein, expressed by CHO , with C-His labeled tag.

研究背景

CD64 蛋白是免疫球蛋白 γ Fc 区的高亲和力受体。它在先天性和适应性免疫反应中发挥作用。CD64 介导单核细胞上的 IgG 效应器功能,触发针对病毒感染细胞的抗体依赖性细胞毒性 (ADCC)。它与 IGHG1 相互作用并与 FCERG1 形成功能信号复合物。CD64 还与 FLNA 相互作用,防止 FCGR1A 降解。此外,它还与 EPB41L2、LAT、PPL、HCK 和 LYN 相互作用,从而发挥其在免疫调节中的多种功能。

种属

Human

表达系统

CHO

标签

C-His

蛋白编号

P12314-1/NP_000557.1 (Q16-P288)

基因 ID
蛋白结构
N-term
CD64 (Q16-P288)
Accession # P12314-1/NP_000557.1
His
C-term
同用名
High affinity immunoglobulin gamma Fc receptor I; Fcgr1; FcRI; CD64
氨基酸序列

MWFLTTLLLWVPVDGQVDTTKAviTLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTP

分子量

45-60 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD64 Protein, Human (CHO, C-His)
目录号:
HY-P72925
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