CD64 蛋白, Mouse (HEK293, His-Avi)

The CD64 protein is a high-affinity receptor for the immunoglobulin gamma Fc region and plays a key role in innate and adaptive immune responses. It prevents FCGR1A degradation by interacting with FCERG1 and FLNA to form a functional signaling complex. CD64 Protein, Mouse (HEK293, His-Avi) is the recombinant mouse-derived CD64 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CD64 Protein, Mouse (HEK293, His-Avi) is 273 a.a., with molecular weight of 45-50 kDa.

CD64 蛋白是一种专为免疫球蛋白 γ Fc 区设计的高亲和力受体，在先天性和适应性免疫反应中发挥着关键作用。其动态功能延伸至通过与 FCERG1 相互作用形成功能性信号复合物。此外，CD64 与 FLNA 相互作用，防止 FCGR1A 降解，并在复杂的细胞过程中与 EPB41L2、LAT 和 PPL 结合。此外，该受体与 HCK 和 LYN 建立联系，展示其多功能性并参与对免疫系统调节至关重要的各种信号级联。

Measured by its binding ability in a functional ELISA. Immobilized CD64 Protein, Mouse (HEK293, His-Avi) at 10 μg/mL (100 μl/well) can bind human IgG1 and the EC₅₀ is 0.07-0.15 μg/mL. Labeled biotin to CD64 Protein, Mouse (HEK293, His-Avi) by a certain molar ratio; Using the Octet RED System, the affinity constant (Kd) of CD64 Protein, Mouse (HEK293, His-Avi) bound to IgG1 Antibody was 5.6 nM.

Mouse

HEK293

C-Avi;C-His

P26151 (E25-P297)

14129  [NCBI]

EVVNATKAVITLQPPWVSIFQKENVTLWCEGPHLPGDSSTQWFINGTAVQISTPSYSIPEASFQDSGEYRCQIGSSMPSDPVQLQIHNDWLLLQASRRVLTEGEPLALRCHGWKNKLVYNVVFYRNGKSFQFSSDSEVAILKTNLSHSGIYHCSGTGRHRYTSAGVSITVKELFTTPVLRASVSSPFPEGSLVTLNCETNLLLQRPGLQLHFSFYVGSKILEYRNTSSEYHIARAEREDAGFYWCEVATEDSSVLKRSPELELQVLGPQSSAP

45-50 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.