CD64 蛋白, Rabbit (HEK293, His)

The CD64 protein is a high-affinity receptor for the immunoglobulin gamma Fc region and plays a key role in innate and adaptive immune responses. It prevents FCGR1A degradation by interacting with FCERG1 and FLNA to form a functional signaling complex. CD64 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived CD64 protein, expressed by HEK293 , with C-His labeled tag.

CD64 蛋白是一种专为免疫球蛋白 γ Fc 区设计的高亲和力受体，在先天性和适应性免疫反应中发挥着关键作用。其动态功能延伸至通过与 FCERG1 相互作用形成功能性信号复合物。此外，CD64 与 FLNA 相互作用，防止 FCGR1A 降解，并在复杂的细胞过程中与 EPB41L2、LAT 和 PPL 结合。此外，该受体与 HCK 和 LYN 建立联系，展示其多功能性并参与对免疫系统调节至关重要的各种信号级联。

Measured by its binding ability in a functional ELISA. Immobilized Rabbit CD64 at 1μg/mL (100μL/well) can bind biotinylated Rabbit IgG. The ED₅₀ for this effect is 1.224 μg/mL.

Rabbit

HEK293

C-6*His

XP_008262732.1 (Q16-F291)

100358696  [NCBI]

MWLWTALLLWVPVGGQEDPTKAVITLQPPWVDVFQEEAVTLQCEGPRQPGDSSAQWFLNGTAIRTLTPRYYITGAQANDSGEYRCQTELSAPSEPVQLQAHRDWLLLQVSGRVFTEGEPLTMRCHAWKNKIVYNVLFYQNGKAFKFSSQDSELTIPKTNVNHNGIYHCSAMGRYRYTSAGVSVTVQELFRVPVLRASSPLPLQEGSAVTLSCETKLLPDSPALRLYFSFYVGNKTVQARNVSSQYQIPRVGGEDLGLYWCEAATEDGGVRKCSVVLELGVLGSQAPNPVWF

Approximately 40-47 kDa due to the glycosylation

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.