KIR3DL2/CD158k 蛋白, Human (HEK293, His-Avi)

KIR3DL2/CD158k is expressed on NK and T cells and recognizes MHC class I, specifically the peptide-free open conformer of HLA-F. Binding to HLA-F negatively regulates NK and T cell effector functions, thereby complexly modulating immune responses. KIR3DL2/CD158k Protein, Human (HEK293, His-Avi) is the recombinant human-derived KIR3DL2/CD158k protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

KIR3DL2/CD158k 是自然杀伤 (NK) 细胞和 T 细胞上表达的受体，在识别 MHC I 类分子中发挥着关键作用。在与不含肽的 HLA-F 开放构象异构体结合后，KIR3DL2 对 NK 和 T 细胞效应器功能产生负面调节影响，有助于免疫反应的复杂调节。除了其免疫细胞作用之外，KIR3DL2 还充当星形胶质细胞上 HLA-F 的受体，通过与 HLA-F 相互作用，可能保护运动神经元免受星形胶质细胞诱导的毒性。这种多方面的参与强调了 KIR3DL2 在免疫调节和神经保护方面的多种功能。

Immobilized Human KIR3DL2, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Anti-KIR3DL2 Antibody, hFc Tag with the EC₅₀ of <0.62μg/ml determined by ELISA.

Human

HEK293

C-Avi;C-His

P43630-1 (L22-L339)

3812  [NCBI]

40-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5-8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.