Neuroserpin 蛋白, Human (CHO)

Neuroserpin Protein, Human (CHO) is a member of the serpin family of serine protease inhibitors, playing an important role in synaptic plasticity and memory formation in the hippocampus.

Neuroserpin 是丝氨酸蛋白酶抑制剂丝氨酸蛋白酶抑制剂家族的成员，主要在神经系统中表达。Neuroserpin 在海马突触可塑性和记忆形成中发挥重要作用。Neuroserpin 表达在中枢神经系统 (CNS) 大部分区域的神经元发育后期尤为突出，而在成人大脑中，其表达仅限于与学习和记忆相关的区域^[1]。

The ED₅₀ determined by a cell proliferation assay using rat C6 cells. The ED50 for this effect is ≤ 2.218 μg/mL, corresponding to a specific activity of ≥ 450.857 units/mg.

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  The ED₅₀ as determined by a cell proliferation assay using rat C6 cells. The ED₅₀ for this effect is 2.218 μg/mL, corresponding to a specific activity is 450.857 units/mg.

Human

CHO

Tag Free

Q99574 (T17-L410)

5274  [NCBI]

TGATFPEEAIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKNGEEFSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEG

40-45 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS or 20 mM PB, 150 mM NaCl, pH 7.4.

< 0.2 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Reumann R, et al. The serine protease inhibitor neuroserpin is required for normal synaptic plasticity and regulates learning and social behavior. Learn Mem. 2017 Nov 15;24(12):650-659.  [Content Brief]