PGLYRP4/PGRP-I beta 蛋白, Human (HEK293, His)

PGLYRP4/PGRP-I beta protein is a model receptor that binds to the cell wall peptide peptidoglycan (PGN) in Gram-positive bacteria and exerts bactericidal activity by interfering with peptidoglycan biosynthesis. Its antimicrobial properties extend to Gram-negative bacteria, although it also binds to them. PGLYRP4/PGRP-I beta Protein, Human (HEK293, His) is the recombinant human-derived PGLYRP4/PGRP-I beta protein, expressed by HEK293 , with C-His labeled tag.

PGLYRP4/PGRP-I β 蛋白是一种模式受体，对革兰氏阳性细菌中发现的胞壁肽聚糖 (PGN) 表现出结合亲和力，显示出针对该细菌群的杀菌活性。其抗菌特性可能归因于其干扰肽聚糖生物合成，从而杀死革兰氏阳性菌。此外，PGLYRP4/PGRP-I beta 表现出针对革兰氏阴性细菌的抑菌活性，尽管也与此类细菌结合。作为先天免疫的一部分，这种蛋白质在识别和应对细菌病原体方面发挥着至关重要的作用。它形成通过二硫键连接的同二聚体，并可以与 PGLYRP3 异二聚化，进一步扩展其在宿主防御机制中的功能库。

Human

HEK293

C-His

Q96LB8-1 (D18-H373)

57115  [NCBI]

DSSWNKTQAKQVSEGLQYLFENISQLTEKGLPTDVSTTVSRKAWGAEAVGCSIQLTTPVNVLVIHHVPGLECHDQTVCSQRLRELQAHHVHNNSGCDVAYNFLVGDDGRVYEGVGWNIQGVHTQGYNNISLGFAFFGTKKGHSPSPAALSAMENLITYAVQKGHLSSSYVQPLLGKGENCLAPRQKTSLKKACPGVVPRSVWGARETHCPRMTLPAKYGIIIHTAGRTCNISDECRLLVRDIQSFYIDRLKSCDIGYNFLVGQDGAIYEGVGWNVQGSSTPGYDDIALGITFMGTFTGIPPNAAALEAAQDLIQCAMVKGYLTPNYLLVGHSDVARTLSPGQALYNIISTWPHFKH

Approximately 50-72 kDa due to the glycosylation

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCL, 100 mM NaCl, pH 8.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.