PRPS1 蛋白, Human (His-SUMO)

The PRPS1 protein plays a crucial role in catalyzing the synthesis of phosphoribosyl pyrophosphate (PRPP), a key intermediate in nucleotide synthesis. By promoting the conversion of ribose 5-phosphate and ATP to PRPP, PRPS1 contributes to the availability of PRPP in various cellular processes, including de novo biosynthesis of purine and pyrimidine nucleotides. PRPS1 Protein, Human (His-SUMO) is the recombinant human-derived PRPS1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

磷酸核糖焦磷酸合成酶 1 (PRPS1) 是一种催化磷酸核糖焦磷酸 (PRPP) 合成的必需酶，而磷酸核糖焦磷酸是核苷酸生物合成的关键前体。PRPP是嘌呤和嘧啶核苷酸从头生物合成的中心分子，在DNA和RNA合成中发挥着基础作用。PRPS1 促进焦磷酸盐从 ATP 转移到 5-磷酸核糖，生成 PRPP。这种酶活性对于维持细胞核苷酸库和支持依赖于核苷酸可用性的各种细胞过程至关重要。PRPS1 在 PRPP 合成中的作用强调了其在基本细胞功能中的重要性，包括遗传物质的保存和细胞增殖的调节。参考资料：所提供的信息基于截至 2022 年 1 月的一般知识，未引用具体参考资料。

Human

E. coli

N-SUMO;N-6*His

P60891-1 (P2-L318)

5631  [NCBI]

PNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL

50.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.