PXR 蛋白, Human (His)

The PXR protein is a nuclear receptor that acts as a multifunctional transcription factor activated by a variety of endogenous and exogenous compounds. It regulates genes involved in the metabolism and secretion of substances, responding to ligands such as rifampicin, hypericin, gugulin, colupulone, isoflavones, pregnenolone and progesterone. PXR Protein, Human (His) is the recombinant human-derived PXR protein, expressed by E. coli , with N-6*His labeled tag. The total length of PXR Protein, Human (His) is 305 a.a., .

PXR 蛋白是一种核受体，是一种多功能转录因子，可被一系列内源性和外源性化合物激活。它在调节涉及潜在有害物质（包括外源性物质、药物和内源性化合物）的代谢和分泌的多个基因的转录方面发挥着关键作用。由抗生素利福平等各种配体以及金丝桃素、古古脂、colupulone 和异黄酮等植物代谢物激活，对特定配体的反应具有物种特异性。PXR 也会被天然存在的类固醇激活，包括孕烯醇酮和黄体酮。它与 CYP3A4 和 ABCB1/MDR1 等关键基因启动子中的响应元件结合。PXR 与 RXR 联合作用，形成异二聚体并与共激活剂 NCOA1 相互作用。此外，PXR 通过其 NR LBD 结构域与时钟蛋白 CRY1 和 CRY2 进行配体依赖性相互作用，为其调节功能增加了另一层复杂性。

Human

E. coli

N-6*His

O75469 (S130-S434)

8856

39.8 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 50 mM HEPES, 200 mM NaCl, 20% glycerol, pH 7.5, 1 mM DTT.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.