SREC-I/SCARF1 蛋白, Human (HEK293, His)

SREC-I/SCARF1 Protein acts as a multifunctional mediator, facilitating Ac-LDL binding and degradation, suggesting a role in lipid metabolism and adhesion. Involved in neurite-like outgrowth, it interacts with SREC2 and AVIL, forming a complex molecular network. The protein's diverse roles underscore its significance in various cellular processes beyond lipid metabolism. SREC-I/SCARF1 Protein, Human (HEK293, His) is the recombinant human-derived SREC-I/SCARF1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SREC-I/SCARF1 Protein, Human (HEK293, His) is 402 a.a., .

SREC-I/SCARF1 蛋白作为细胞过程中的多功能介质，主要促进乙酰化低密度脂蛋白 (Ac-LDL) 的结合和降解。除了在脂质代谢中的作用外，该蛋白质还涉及异嗜性相互作用，表明其具有粘附蛋白的功能。此外，SREC-I/SCARF1 参与神经突样生长的调节，进一步强调了其在细胞动力学中的多种作用。该蛋白通过其胞外结构域与 SREC2 发生异嗜性相互作用，这种相互作用在 Ac-LDL 等配体存在的情况下被抑制。值得注意的是，SREC-I/SCARF1 还与 AVIL 相互作用，有助于形成其复杂的分子关联网络，并强调其参与各种细胞过程。

Measured by its binding ability in a functional ELISA. When Human AcLDL is immobilized at 10 µg/mL (100 µL/well) can bind Human SREC-I/SCARF1. The ED₅₀ for this effect is 48.05 ng/mL.

Human

HEK293

C-6*His

Q14162 (S20-T421)

8578

SELDPKGQHVCVASSPSAELQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRCSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPGSGSRDT

Approximately 58-70 kDa due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<0.1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in PBS. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.