TMP21/p23 蛋白, Human (HEK293, Fc)

TMP21/p23 proteins act as cargo receptors in endoplasmic reticulum (ER) and Golgi vesicle trafficking, mediating quality control. TMP21/p23 Protein, Human (HEK293, Fc) is the recombinant human-derived TMP21/p23 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TMP21/p23 Protein, Human (HEK293, Fc) is 154 a.a., with molecular weight of ~44 KDa.

TMP21/p23 是内质网 (ER) 和高尔基体中蛋白质囊泡运输和质量控制不可或缺的货物受体，在协调囊泡外壳形成和货物运输中发挥着至关重要的作用。它主要在早期分泌途径中发挥作用，在 ER、ER-高尔基体中间室 (ERGIC) 和高尔基体之间循环。值得注意的是，TMP21/p23 在顺行和逆行囊泡介导的运输中发挥作用，参与 GPI 锚定蛋白的运输并影响 COPI 囊泡的生物发生。除了其货物受体活性之外，TMP21/p23 还可以充当蛋白质通道，促进无前导细胞质货物易位到 ERGIC 中。此外，它还参与调节各种蛋白质的运输，包括 G 蛋白偶联受体，有助于受体再敏化。TMP21/p23 与其他 p24 家族成员形成复合物，并与囊泡外壳机制的多个组件相互作用，突出了其在细胞内蛋白质转运中的多方面作用。

Human

HEK293

C-mFc

P49755/NP_006818.3 (I32-R185)

10972  [NCBI]

ISFHLPINSRKCLREEIHKDLLVTGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESKGTGRIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTR

Approximately 45-50 kDa.

Greater than 90% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.