TNKS1 蛋白, Human

The TNKS1 protein is a polyADP-ribosyltransferase that is integral to multiple cellular processes, including the Wnt signaling pathway, telomere length regulation, and vesicle trafficking. In Wnt signaling, TNKS1 activates this pathway by poly-ADP-ribosylating AXIN1 and AXIN2, promoting their degradation. TNKS1 Protein, Human is the recombinant human-derived TNKS1 protein, expressed by E. coli , with tag free. The total length of TNKS1 Protein, Human is 235 a.a., .

TNKS1 是一种多聚 ADP 核糖基转移酶，在多种细胞过程中发挥着关键作用，包括 Wnt 信号通路、端粒长度调节和囊泡运输。在 Wnt 信号级联中，TNKS1 通过介导 β-连环蛋白破坏复合物关键成分（即 AXIN1 和 AXIN2）的多聚 ADP 核糖基化 (PARsylation) 充当激活剂。这种修饰有助于 RNF146 识别它们，从而导致泛素化和随后的降解。TNKS1 还通过 TERF1 的 PARsylation 参与端粒长度的调节。此外，它通过介导 HEPACAM2/MIKI 的 PARsylation 参与中期的中心体成熟，并可能通过调节 SLC2A4/GLUT4 囊泡的亚细胞分布来影响囊泡运输。此外，TNKS1 通过 NUMA1 的 PARsylation 参与纺锤体极组装，并有助于刺激 26S 蛋白酶体活性，突出其在细胞生理学中的多方面功能。

Human

E. coli

Tag Free

O95271 (Q1091-Q1325)

8658

26.8 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of 50 mM HEPES, 200 mM NaCl, 20% glycerol, 1 mM DTT, pH 7.5.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.