ULBP1/RAET1I 蛋白, Mouse (HEK293, His)

UL16 binding protein 1 (Ulbp1) is a membrane ligand of natural killer group 2, member D (NKG2D) which activates immune system on NK cells and T cells. Binding of Ulbp1 to NKG2D leads to activation of JAK2, STAT5, ERK and PI3K/Akt pathways, positive regulating immune response, interferon-gamma production and leukocyte activation. The effect of Ulbp1 can be inhibited by binding to UL16. ULBP1/RAET1I Protein, Mouse (HEK293, His) is the recombinant mouse-derived ULBP1/RAET1I protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ULBP1/RAET1I Protein, Mouse (HEK293, His) is 186 a.a., with molecular weight of 30-40 kDa.

UL16 结合蛋白 1 (Ulbp1) 是自然杀伤组 2 成员 D (NKG2D) 的膜配体，是 NK 细胞和 T 细胞上的免疫系统激活受体。Ulbp1 与 NKG2D 结合可激活多种信号转导通路，包括 JAK2、STAT5、ERK 和 PI3K/Akt。Ulbp1 参与免疫应答、干扰素 γ 产生和白细胞活化的正向调节。此外，在巨细胞病毒感染的细胞中，Ulbp1 被 UL16 糖蛋白结合，阻止其对免疫系统的激活^[1][2]。

Mouse

HEK293

C-6*His

Q8HWA3 (P26-T211)

77777  [NCBI]

PRIEETASLCNIYKVNRSESGQHSHEVQGLLNRQPLFVYKDKKCHAIGAHRNSMNATKICEKEVDTLKDGIDIFKGLLLHIVQETNTTGKPLTLQAEVCGQYEVDKHFTGYAIVSLNGKNIFRVDTSTGNWTQLDHEFEKFIEMCKEDKVLAAFLKKTTEGDCRTWLDELMLHWKEHLEPAGSFST

30-40 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.