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  4. ULBP1/RAET1I 蛋白, Human (HEK293, His-Avi)

ULBP1/RAET1I 蛋白, Human (HEK293, His-Avi)

目录号: HY-P78535
产品使用指南

ULBP1/RAET1I 蛋白在自然杀伤细胞的细胞毒性中至关重要，可结合并激活 KLRK1/NKG2D 受体。该机制强调了 ULBP1/RAET1I 在介导细胞毒性反应中的重要性。值得注意的是，ULBP1/RAET1I 不结合 β2-微球蛋白，这强调了其与 KLRK1/NKG2D 结合的特异性和选择性。这种独特的相互作用特征凸显了 ULBP1/RAET1I 在免疫反应中的关键作用及其作为调节自然杀伤细胞活性的治疗靶点的潜力。ULBP1/RAET1I 蛋白, Human (HEK293, His-Avi) 是重组的 ULBP1/RAET1I 蛋白，由 HEK293 表达，带有 C-Avi, C-His 标签。ULBP1/RAET1I 蛋白, Human (HEK293, His-Avi) 全长 190 个氨基酸，分子量为 28-35 kDa。

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描述

ULBP1/RAET1I Protein is crucial in natural killer cell cytotoxicity, binding to and activating the KLRK1/NKG2D receptor. This mechanism underscores ULBP1/RAET1I's significance in mediating cytotoxic responses. Notably, ULBP1/RAET1I does not bind beta2-microglobulin, emphasizing its specificity and selectivity in engaging KLRK1/NKG2D. This distinct interaction profile highlights ULBP1/RAET1I's pivotal role in immune responses and its potential as a therapeutic target for modulating natural killer cell activity. ULBP1/RAET1I Protein, Human (HEK293, His-Avi) is the recombinant human-derived ULBP1/RAET1I protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of ULBP1/RAET1I Protein, Human (HEK293, His-Avi) is 190 a.a., with molecular weight of 28-35 kDa.
研究背景

ULBP1/RAET1I 蛋白作为配体结合并激活 KLRK1/NKG2D 受体，在自然杀伤细胞的细胞毒性中发挥着至关重要的作用。这种结合和激活机制凸显了 ULBP1/RAET1I 在介导自然杀伤细胞的细胞毒性反应中的重要性。此外，值得注意的是 ULBP1/RAET1I 不表现出与 β2-微球蛋白的结合。这种特征性相互作用特征强调了 ULBP1/RAET1I 在与 KLRK1/NKG2D 结合中的特异性和选择性，强调其在免疫反应中的关键作用及其作为调节自然杀伤细胞活性的治疗靶点的潜力。
种属

Human
表达系统

HEK293
标签

C-Avi;C-His
蛋白编号

Q9BZM6 (G26-P215)
基因 ID
蛋白结构
N-term
ULBP1 (G26-P215)
Accession # Q9BZM6
His-Avi
C-term
同用名
ALCAN-beta; NKG2D ligand 1; N2DL-1; NKG2DL1; MULT-1; NKG2DL; AET1I; ULBP1; ULBP-1; ALCAN-β
分子量

28-35 kDa
纯度

Greater than 95% as determined by Tris-Bis PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

ULBP1/RAET1I Protein, Human (HEK293, His-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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