2. Anti-infection
  3. RSV Influenza Virus
  4. RSV/IAV-IN-3

RSV/IAV-IN-3 (compound 14'i) 是呼吸道合胞病毒 (RSV) 和甲型流感病毒 (IAV) 的双重抑制剂，EC50 值分别为 2.92 µM 和 1.90 µM。RSV/IAV-IN-3 对 H1N1 和 H3N2 具有抗病毒作用，在 MDCK 细胞中的 EC50 值分别为 3.25 µM 和 1.50 µM。RSV/IAV-IN-3 以剂量依赖性方式显着抑制荧光素酶的活性，EC50 值为 3.89 µM。RSV/IAV-IN-3 抑制 IAV 感染和 RdRp 活性。RSV/IAV-IN-3 在进入后阶段抑制 IAV 和 RSV 复制。

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RSV/IAV-IN-3 Chemical Structure

RSV/IAV-IN-3 Chemical Structure

CAS No. : 2395007-81-3

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RSV/IAV-IN-3 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RSV/IAV-IN-3 (compound 14'i) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza A virus (IAV) with EC50 values of 2.92 µM and 1.90 µM,respectively. RSV/IAV-IN-3 has antiviral effect against H1N1 and H3N2 with EC50 values of 3.25 µM and 1.50 µM in MDCK cells, respectively. RSV/IAV-IN-3 significantly inhibits the activity of luciferase in a dose-dependent manner, with an EC50 of 3.89 µM. RSV/IAV-IN-3 inhibits IAV infectivity and RdRp activity. RSV/IAV-IN-3 inhibits IAV and RSV replication at the post-entry stage[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK-293T CC50
> 100 μM
Compound: 14'i
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
[PMID: 31734025]
HEp-2 CC50
9.65 μM
Compound: 14'i
Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human HEp-2 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
[PMID: 31734025]
分子量

435.33

Formula

C19H19BrN2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RSV/IAV-IN-3 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RSV/IAV-IN-32395007-81-3RSVInfluenza VirusRespiratory syncytial virusrespiratory syncytial virusinfluenza A virusIAVH1N1H3N2MDCKluciferaseRdRpreplicationpost-entry stageInhibitorinhibitorinhibit

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