2. Anti-infection
  3. Fungal
  4. Seselin

Seselin 是一种抗癌、抗炎、抗真菌剂，具有口服活性。

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Seselin Chemical Structure

Seselin Chemical Structure

CAS No. : 523-59-1

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规格 价格 是否有货 数量
1 mg ￥1100
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5 mg ￥2500
In-stock
10 mg ￥4200
In-stock
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100 mg   询价  

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Customer Review

Seselin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Seselin is an anticancer, antinociceptive, anti-inflammatory and antifungal agent. Seselin is orally active[1][2][3].

体外研究
(In Vitro)

Seselin 对 P-388 和 HT-29 细胞有毒性，ED50 分别为 8.66 和 9.94 μg/mL [1]。
Seselin (5-20 μM; 0.5-24 h) 抑制 LPS 和 IFN-γ 刺激的巨噬细胞的细胞因子输出[3]。
Seselin (5-20 μM; 12 h) 抑制 BMDMs 中促炎巨噬细胞标志物 (iNOS、phagocytosis、CD11c) 的表达[3]。
Seselin (5-20 μM; 0.5-6 h) 阻断 STAT1 信号通路[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Seselin 相关抗体:

RT-PCR[3]

Cell Line: Bone marrow-derived macrophages (BMDMs)
Concentration: 5, 10 and 20 μM
Incubation Time: 6 h
Result: Reduced the mRNA for cytokines (IL-1β, IL-6, Tnf-α and IL-23) and chemokines (Ccl3, Ccl7, Cxcl9 and Cxcl11) concentration-dependently in BMDMs.

Western Blot Analysis[3]

Cell Line: BMDMs
Concentration: 5, 10 and 20 μM
Incubation Time: 0.5, 1.5, 3 and 6 h
Result: Suppressed expression of p-STAT1 and p-p65 both concentration and time dependently.
体内研究
(In Vivo)

Seselin (0.5-40.5 mg/kg; s.c.; once) 在小鼠中显示外周抗炎和抗伤感受活性[2]。
Seselin (3-30 mg/kg; i.g.; once) 改善小鼠盲肠结扎和穿刺引起的脓毒症[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice[2]
Dosage: 0.5, 4.5 or 40.5 mg/kg
Administration: Subcutaneous injection; once
Result: Inhibited the writhing response induced by acetic acid in a significant and dose-dependent manner, by 19.5%, 26.2% and 41.4% at dose of 0.5, 4.5 or 40.5 mg/kg, respectively. Elicited a significant inhibition of formalin response during the second phase (inflammatory), by 90.3%, 97.8% and 95.3%, respectively.
Animal Model: C57BL/6 mice, caecal ligation and puncture (CLP) induced sepsis model[3]
Dosage: 3, 10 and 30 mg/kg
Administration: Intragastric administration, once
Result: Ameliorated lung injury and decreased JAK2 phosphorylation level in lung tissue during sepsis. Reduced the immune cell counts in BALF induced by CLP.
分子量

228.24

Formula

C14H12O3
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 98.48%

COA (268 KB) HNMR (119 KB)

产品使用指南 (1538 KB)
参考文献

Seselin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Seselin523-59-1FungalP-388HT-29BMDMsiNOSphagocytosisCD11cCcl3Ccl7Cxcl9Cxcl11IL-1βIL-6Tnf-αIL-23Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-W505771
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