2. Protein Tyrosine Kinase/RTK PROTAC Metabolic Enzyme/Protease Apoptosis
  3. SHP2 PROTACs Phosphatase Apoptosis
  4. SHP2 protein degrader-1

SHP2 protein degrader-1 

目录号: HY-145159 纯度: 98.94%
COA 产品使用指南

摩尔计算器

SHP2 protein degrader-1 是一种有效的 SHP2 变构抑制剂。SHP2 蛋白降解剂-1 诱导 SHP2 降解和细胞凋亡。SHP2 蛋白降解剂-1 具有研究 SHP2 相关疾病的潜力。

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SHP2 protein degrader-1 Chemical Structure

SHP2 protein degrader-1 Chemical Structure

CAS No. : 2624181-69-5

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规格 价格 是否有货 数量
1 mg ￥4850
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Customer Review

SHP2 protein degrader-1 相关抗体

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SHP2 protein degrader-1 is a potent allosteric inhibitor of SHP2. SHP2 protein degrader-1 induces SHP2 degradation and cell apoptosis. SHP2 protein degrader-1 has the potential for researching SHP2 related diseases[1].

IC50 & Target

SHP2[1]
体外研究
(In Vitro)

SHP2 protein degrader-1 (compound SP4) (0-200 μM; 24 hours) inhibits the growth of Hela cells, with IC50 of 5.77 and 4.30 nM, respectively, which are about 100 times higher than the activity of SHP099 (SHP2 inhibitor)[1].
SHP2 protein degrader-1 (compound SP4) (0-200 μM; 96 hours) induces 54.01% apoptotic death compared with 0.13% of the control at 100 nM[1].
SHP2 protein degrader-1 (compound SP4) (0-200 μM; 96 hours) induces cell cycle arrested at the G1 phase in Hela cells[1].
SHP2 protein degrader-1 (compound SP4) (0-200 μM; 96 hours) significantly inhibits the phosphorylation of JNK, Erk and p38[1].
SHP2 protein degrader-1 (compound SP4) (0-200 μM; 96 hours) inhibits RAS/MAPK signaling and cellular responses by a mechanism involving inhibition of SHP2 catalytic activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SHP2 protein degrader-1 相关抗体:

Cell Viability Assay[1]

Cell Line: Hela cells
Concentration: 0-200  μM
Incubation Time: 24 hours
Result: Strongly inhibited the growth of Hela cells, with IC50 of 5.77 and 4.30 nM, respectively, which were about 100 times higher than the activity of SHP099 (SHP2 inhibitor).

Apoptosis Analysis[1]

Cell Line: Hela cells
Concentration: 0-100  μM
Incubation Time: 96 hours
Result: Induced 54.01% apoptotic death compared with 0.13% of the control at 100 nM. While SHP099 at 1000 nM could induce 33.74% apoptotic death compared with 0.13% of the control.

Cell Cycle Analysis[1]

Cell Line: Hela cells
Concentration: 0-100  μM
Incubation Time: 96 hours
Result: Induced cell cycle arrested at the G1 phase in Hela cells.

Western Blot Analysis[1]

Cell Line: Hela cells
Concentration: 0-100  μM
Incubation Time: 96 hours
Result: Significantly inhibited the phosphorylation of JNK, Erk and p38.
分子量

908.83

Formula

C42H51Cl2N11O8
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 110 mg/mL (121.03 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1003 mL 5.5016 mL 11.0032 mL
5 mM 0.2201 mL 1.1003 mL 2.2006 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

SHP2 protein degrader-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1003 mL 5.5016 mL 11.0032 mL 27.5079 mL
5 mM 0.2201 mL 1.1003 mL 2.2006 mL 5.5016 mL
10 mM 0.1100 mL 0.5502 mL 1.1003 mL 2.7508 mL
15 mM 0.0734 mL 0.3668 mL 0.7335 mL 1.8339 mL
20 mM 0.0550 mL 0.2751 mL 0.5502 mL 1.3754 mL
25 mM 0.0440 mL 0.2201 mL 0.4401 mL 1.1003 mL
30 mM 0.0367 mL 0.1834 mL 0.3668 mL 0.9169 mL
40 mM 0.0275 mL 0.1375 mL 0.2751 mL 0.6877 mL
50 mM 0.0220 mL 0.1100 mL 0.2201 mL 0.5502 mL
60 mM 0.0183 mL 0.0917 mL 0.1834 mL 0.4585 mL
80 mM 0.0138 mL 0.0688 mL 0.1375 mL 0.3438 mL
100 mM 0.0110 mL 0.0550 mL 0.1100 mL 0.2751 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHP2 protein degrader-12624181-69-5SHP2PROTACsPhosphataseApoptosisSrc homology phosphatase 2PTPN11degradationapoptosisallosteric inhibitorInhibitorinhibitorinhibit

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