2. Stem Cell/Wnt
  3. PKG
  4. Sp-8-Br-PET-cGMPS

Sp-8-Br-PET-cGMPS 是一种膜渗透性的 PKG 激动剂，也是膜渗透性视网膜型 cGMP 门控离子通道 (cGMP-gated ion channel) 抑制剂，以及作为 cGMP 依赖性蛋白激酶 I α 和 I β 的激活剂。Sp-8-Br-PET-cGMPS 对哺乳动物环核苷酸依赖性磷酸二酯酶具有抗性，无代谢副作用，与 Sp-8-pCPT-cGMPS 相比，亲脂性和渗透性更强。Sp-8-Br-PET-cGMPS 可用于研究 cGMP 信号通路在神经系统中的作用。

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Sp-8-Br-PET-cGMPS Chemical Structure

Sp-8-Br-PET-cGMPS Chemical Structure

CAS No. : 172806-21-2

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Other Forms of Sp-8-Br-PET-cGMPS:

Sp-8-Br-PET-cGMPS 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sp-8-Br-PET-cGMPS is a membrane-permeable PKG agonist and a membrane-permeable inhibitor of retinal-type cGMP-gated ion channels, as well as an activator of cGMP-dependent protein kinases I α and I β. Sp-8-Br-PET-cGMPS is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, has no metabolic side effects, and is more lipophilic and permeable than Sp-8-pCPT-cGMPS. Sp-8-Br-PET-cGMPS can be used to study the role of cGMP signaling pathways in the nervous system[1].

分子量

540.28

Formula

C18H15BrN5O6PS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Sp-8-Br-PET-cGMPS 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Sp-8-Br-PET-cGMPS172806-21-2PKGMembrane permeabilityagonistlipophilicitynervous systemInhibitorinhibitorinhibit

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