2. Anti-infection
  3. Bacterial Antibiotic
  4. Sparfloxacin

Sparfloxacin  (Synonyms: 司帕沙星; CI-978; AT-4140)

目录号: HY-B0308 纯度: 99.93%
COA 产品使用指南

摩尔计算器

Sparfloxacin (CI-978) 是氟喹诺酮类抗菌素。

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Sparfloxacin Chemical Structure

Sparfloxacin Chemical Structure

CAS No. : 110871-86-8

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Customer Review

Other Forms of Sparfloxacin:

Sparfloxacin 相关抗体

Top Publications Citing Use of Products

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sparfloxacin (CI-978) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity[1].

IC50 & Target

Quinolone

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
88.8 μM
Compound: sparfloxacin
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits
[PMID: 23812503]
HEK293 IC50
> 250 μM
Compound: Sparfloxacin
Binding affinity to human ERG F656A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -120 mV by patch clamp method
Binding affinity to human ERG F656A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -120 mV by patch clamp method
[PMID: 23711922]
HEK293 IC50
> 250 μM
Compound: Sparfloxacin
Binding affinity to human ERG Y652A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
Binding affinity to human ERG Y652A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
[PMID: 23711922]
HEK293 IC50
127.6 μM
Compound: Sparfloxacin
Binding affinity to human ERG Y652A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
Binding affinity to human ERG Y652A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
[PMID: 23711922]
HEK293 IC50
21.7 μM
Compound: Sparfloxacin
Binding affinity to wild type human ERG expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
Binding affinity to wild type human ERG expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
[PMID: 23711922]
HEK293 IC50
33.6 μM
Compound: Sparfloxacin
Binding affinity to human ERG F656A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -120 mV by patch clamp method
Binding affinity to human ERG F656A tandem dimeric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -120 mV by patch clamp method
[PMID: 23711922]
HEK293 IC50
46.9 μM
Compound: Sparfloxacin
Binding affinity to human ERG S624A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
Binding affinity to human ERG S624A tetrameric mutant expressed in HEK293 cells assessed as inhibition of tail current measured upon repolarization to -40 mV by patch clamp method
[PMID: 23711922]
NIH3T3 IC50
122 μM
Compound: Sparfloxacin
Inhibition of mouse NIH/3T3 cell proliferation by MTT assay
Inhibition of mouse NIH/3T3 cell proliferation by MTT assay
[PMID: 19595598]
体外研究
(In Vitro)

Sparfloxacin (CI-978) shows broad and potent antibacterial activity. Its MICs for 90% of the strains tested are 0.1 to 0.78 μg/ml against gram-positive organisms, such as members of the genera Staphylococcus , Streptococcus and Enterococcus , and 0.0125 to 1.56 μg/ml against gram-negative organisms, such as members of the family Enterobacteriaceae and the genera Pseudomona . Its MICs are 0.025 to 0.78 μg/ml against glucose nonfermenters, 0.2 to 0.78 μg/ml against anaerobes, 0.0125 to 0.05 μg/ml against Legionella. Sparfloxacin (CI-978) showed good oral efficacy against systemic infections with Staphylococcus aureus , Streptococcus pyogenes , Streptococcus pneumoniae , Escherichia coli , and Pseudomonas aeruginosa in mice[1]. Sparfloxacin targets DNA gyrase and inhibits DNA synthesis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sparfloxacin 相关抗体:
分子量

392.40

Formula

C19H22F2N4O3
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

司帕沙星
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

0.1 M NaOH 中的溶解度 : 50 mg/mL (127.42 mM; ultrasonic and adjust pH to 11 with NaOH)

DMSO 中的溶解度 : 5 mg/mL (12.74 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5484 mL 12.7421 mL 25.4842 mL
5 mM 0.5097 mL 2.5484 mL 5.0968 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.93%

COA (288 KB) HNMR (255 KB) LCMS (92 KB)

产品使用指南 (1538 KB)
参考文献

Sparfloxacin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / 0.1 M NaOH 1 mM 2.5484 mL 12.7421 mL 25.4842 mL 63.7105 mL
5 mM 0.5097 mL 2.5484 mL 5.0968 mL 12.7421 mL
10 mM 0.2548 mL 1.2742 mL 2.5484 mL 6.3711 mL
0.1 M NaOH 15 mM 0.1699 mL 0.8495 mL 1.6989 mL 4.2474 mL
20 mM 0.1274 mL 0.6371 mL 1.2742 mL 3.1855 mL
25 mM 0.1019 mL 0.5097 mL 1.0194 mL 2.5484 mL
30 mM 0.0849 mL 0.4247 mL 0.8495 mL 2.1237 mL
40 mM 0.0637 mL 0.3186 mL 0.6371 mL 1.5928 mL
50 mM 0.0510 mL 0.2548 mL 0.5097 mL 1.2742 mL
60 mM 0.0425 mL 0.2124 mL 0.4247 mL 1.0618 mL
80 mM 0.0319 mL 0.1593 mL 0.3186 mL 0.7964 mL
100 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.6371 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sparfloxacin110871-86-8CI-978 AT-4140司帕沙星CI978CI 978AT4140AT 4140AT-4140BacterialAntibioticInhibitorinhibitorinhibit

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