2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. STAT3-IN-4

STAT3-IN-4 (compound B9) 是一种 STAT3 抑制剂，对 STAT3 (I634S/Q635G) 和 WT 的 Kd 值分别为 22.75 和 4.59 μM。STAT3-IN-4 可抑制肿瘤细胞增殖。

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STAT3-IN-4 Chemical Structure

STAT3-IN-4 Chemical Structure

CAS No. : 825611-06-1

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STAT3-IN-4 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STAT3-IN-4 (compound B9) is a STAT3 inhibitor with Kd values for STAT3 (I634S/Q635G) and WT are 22.75 and 4.59 μM, respectively. STAT3-IN-4 can inhibit the proliferation of tumor cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DU-145 IC50
63.77 μM
Compound: B9
Antiproliferative activity against human DU-145 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human DU-145 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
[PMID: 27727126]
MCF7 IC50
133.7 μM
Compound: B9
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
[PMID: 27727126]
MDA-MB-231 IC50
13.8 μM
Compound: B9
Antiproliferative activity against human MDA-MB-231 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human MDA-MB-231 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
[PMID: 27727126]
MDA-MB-468 IC50
5.1 μM
Compound: B9
Antiproliferative activity against human MDA-MB-468 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human MDA-MB-468 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
[PMID: 27727126]
分子量

379.39

Formula

C20H13NO5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STAT3-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-4825611-06-1STATSTAT3InhibitorAntitumorMDA-MB-468DU145inhibitorinhibit

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目录号：
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