2. Epigenetics
  3. TET Protein
  4. TETi76

TETi76 是一种具有口服活性的 TET 家族抑制剂，对 TET1, TET2 和 TET3 的 IC50 值分别为 1.5, 9.4 和 8.8 μM。TETi76 通过与 TET 酶的活性位点竞争性结合，在体外和体内降低 TET2 突变体的胞嘧啶羟甲基化和限制克隆生长，但不影响正常造血前体细胞的生长。TETi76 可用于白血病的研究。

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TETi76 Chemical Structure

TETi76 Chemical Structure

CAS No. : 1451750-73-4

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规格 价格 是否有货 数量
5 mg ￥1120
In-stock
10 mg ￥1820
In-stock
25 mg ￥3710
In-stock
50 mg ￥5950
In-stock
100 mg   询价  
200 mg   询价  

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Customer Review

TETi76 相关抗体

Top Publications Citing Use of Products

查看 TET Protein 亚型特异性产品:

查看所有亚型
TET1 TET2 TET3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TETi76 is an orally active TET family inhibitor with IC50 values ??of 1.5, 9.4 and 8.8 μM for TET1, TET2 and TET3, respectively. TETi76 competitively binds to the active site of TET enzymes, reduces cytosine hydroxymethylation and restricts clonal growth of TET2 mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research[1].

IC50 & Target[1]

TET1

1.5 μM (IC50)

TET2

9.4 μM (IC50)

TET3

8.8 μM (IC50)

分子量

216.23

Formula

C10H16O5
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

纯度 & 产品资料

纯度: 97.49%

COA (281 KB) HNMR (201 KB) LCMS (146 KB)

产品使用指南 (1538 KB)
参考文献

TETi76 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TETi761451750-73-4TETi 76TETi-76TET ProteinTET enzymeTen-eleven-translocation (TET) proteinTen-eleven translocation (TET) methylcytosine dioxygenaseCompetitive inhibitionactive sitehydroxymethylationleukemiaInhibitorinhibitorinhibit

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目录号：
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