1. Cell Cycle/DNA Damage
  2. Topoisomerase DNA/RNA Synthesis
  3. Tilatamig samrotecan

Tilatamig samrotecan  (Synonyms: AZD9592)

目录号: HY-171124
产品使用指南 技术支持

Tilatamig samrotecan (AZD9592) 是一种用于递送拓扑异构酶I抑制剂 (TOP1i) 的 ADC,其靶向表皮生长因子受体 (EGFR) 和 c-MET,具有抗肿瘤活性。Tilatamig samrotecan (AZD9592) 可诱导 DNA 双链断裂,增加 pRAD50 和 γH2AX 的表达,抑制非小细胞肺癌生长。

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Tilatamig samrotecan Chemical Structure

Tilatamig samrotecan Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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查看 Topoisomerase 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tilatamig samrotecan (AZD9592) is an antibody-drug conjugate (ADC) used to deliver topoisomerase I inhibitors (TOP1i), targeting the epidermal growth factor receptor (EGFR) and c-MET, with anti-tumor activity. Tilatamig samrotecan (AZD9592) can induce DNA double-strand breaks, increase the expression of pRAD50 and γH2AX, and inhibit the growth of non-small cell lung cancer[1][2].

IC50 & Target

Topoisomerase I

 

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Tilatamig samrotecan
目录号:
HY-171124
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