2. Epigenetics Cell Cycle/DNA Damage Apoptosis MAPK/ERK Pathway
  3. PARP Necroptosis Topoisomerase RIP kinase Mixed Lineage Kinase
  4. Topoisomerase I/II inhibitor 8

opoisomerase I/II inhibitor 8 (Compound Ru7) 是一种 Topoisomerase I/II 的双催化抑制剂，能诱导 DNA 损伤和 PARP-1 激活，进而通过 RIPK1、RIPK3 和 MLKL 的激活，最终引发坏死性凋亡 (necroptosis)。Topoisomerase I/II inhibitor 8 具有显著的抗癌活性，可有效靶向癌细胞的细胞核，通过坏死性凋亡诱导细胞死亡，在癌症中规避耐药性方面具有巨大的临床潜力。

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Topoisomerase I/II inhibitor 8 Chemical Structure

Topoisomerase I/II inhibitor 8 Chemical Structure

CAS No. : 355400-87-2

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Topoisomerase I/II inhibitor 8 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Topoisomerase Topo I Topo II

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  • 生物活性

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生物活性

Topoisomerase I/II Inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of Topoisomerase I/II, capable of inducing DNA damage and PARP-1 activation, which subsequently leads to the activation of RIPK1, RIPK3, and MLKL, ultimately triggering necroptosis. Topoisomerase I/II Inhibitor 8 demonstrates remarkable anticancer activity by effectively targeting the nuclei of cancer cells and inducing cell death through necroptosis, showing great clinical potential in circumventing drug resistance in cancer treatment[1].

分子量

497.18

Formula

C14H11Br2NO5S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Topoisomerase I/II inhibitor 8 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase I/II inhibitor 8355400-87-2PARPNecroptosisTopoisomeraseRIP kinaseMixed Lineage Kinasepoly ADP ribose polymerase Receptor-interacting protein kinasesRIPKMLKsnecroptosisA549anticancer activitydrug resistanceInhibitorinhibitorinhibit

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