2. Cell Cycle/DNA Damage Apoptosis Autophagy
  3. Topoisomerase Apoptosis Autophagy
  4. Topotecan hydrochloride hydrate

Topotecan hydrochloride hydrate  (Synonyms: SKF 104864A hydrochloride hydrate; NSC 609669 hydrochloride hydrate)

目录号: HY-13768C
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摩尔计算器

Topotecan hydrochloride hydrate 是一种口服有效的拓扑异构酶 I (Topoisomerase I) 抑制剂。Topotecan hydrochloride hydrate 诱导细胞周期阻滞在 G0/G1 和 S 期，促进凋亡 (apoptosis)。Topotecan hydrochloride hydrate 具有抗癌活性。

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Topotecan hydrochloride hydrate Chemical Structure

Topotecan hydrochloride hydrate Chemical Structure

CAS No. : 1044663-62-8

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Topotecan hydrochloride hydrate 的其他形式现货产品:

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Other Forms of Topotecan hydrochloride hydrate:

Topotecan hydrochloride hydrate 相关抗体

Top Publications Citing Use of Products

    Topotecan hydrochloride hydrate purchased from MCE. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761.  [Abstract]

    IB analysis of the level of cleaved-caspase 3 and cleaved-PARP1 in the indicated chemotherapy-treated xenograft tumors. GAPDH served as the loading control.

    Topotecan hydrochloride hydrate purchased from MCE. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761.  [Abstract]

    WDR5 inhibitor OICR-9429 enhances the sensitivity of ovarian cancer to genotoxic chemotherapeutics in vivo. Representative images and the apoptotic rate the indicated chemotherapy-treated xenograft tumors.

    查看 Topoisomerase 亚型特异性产品:

    查看所有亚型
    Topoisomerase Topo I Topo II

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity[1].

    IC50 & Target

    Topoisomerase I

     

    体外研究
    (In Vitro)

    Topotecan hydrochloride hydrate obviously inhibits proliferation of human glioma cells and glioma stem cells (GSCs) in a dose- and time-dependent manner[1].
    Topotecan hydrochloride hydrate (0-40 μM) obviously inhibits the cell viability compared with the control groups, in a dose-dependent manner[1].
    Topotecan hydrochloride hydrate shows anti-proliferation activity against U251, U87, GSCs-U251 and GSCs-U87 cells, with IC50 values of 2.73±0.25, 2.95±0.23, 5.46±0.41, and 5.95±0.24 μM, respectively[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Topotecan hydrochloride hydrate 相关抗体:
    体内研究
    (In Vivo)

    Topotecan hydrochloride hydrate (0.5, 1.0, and 1.5 mg/kg; Orally, daily) causes greater reduction in microvascular density in an ovarian cancer model, but the mice treated with 1.5 mg/kg daily, oral Topotecan show decreased food intake, and a lesser antitumor effect[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    475.92

    Formula

    C23H26ClN3O6
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Topotecan hydrochloride hydrate 相关分类

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    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Topotecan hydrochloride1044663-62-8SKF 104864A hydrochlorideNSC 609669 hydrochlorideTopoisomeraseApoptosisAutophagyU251U87GSCs-U251GSCs-U87orally activeInhibitorinhibitorinhibit

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