2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. TP3011

TP3011 (CH0793011) 是 CH-0793076 的活性代谢产物 (metabolite)，是与 SN38 等价的有效拓扑异构酶 I (topoisomerase I) 抑制剂。TP3011 在 IC50 亚纳摩尔范围内可抵抗癌细胞系的生长。

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TP3011 Chemical Structure

TP3011 Chemical Structure

CAS No. : 534605-74-8

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TP3011 相关抗体

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TP3011 (CH0793011) is an active metabolite of CH-0793076 and is a potent topoisomerase I inhibitor equipotent as SN38[1]. TP3011 is against cancer cell lines growth with IC50s at the range sub-nanomolar in vitro[2].

IC50 & Target[1]

Topoisomerase I

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
0.85 nM
Compound: 6c
Antiproliferative activity against human HCT116 cells after 3 days
Antiproliferative activity against human HCT116 cells after 3 days
[PMID: 19254843]
NCI-H460 IC50
8.2 nM
Compound: 6c
Antiproliferative activity against human NCI-H460 cells after 3 days
Antiproliferative activity against human NCI-H460 cells after 3 days
[PMID: 19254843]
QG-56 IC50
8.5 nM
Compound: 6c
Antiproliferative activity against human QG56 cells after 3 days
Antiproliferative activity against human QG56 cells after 3 days
[PMID: 19254843]
体外研究
(In Vitro)

TP3011 (0-100 nM; 72 hours) (compound 6c) inhibits cell proliferative activities against various human cancer cell lines, producing 50% inhibition (IC50) of cell growth of 0.85 nM; 8.5 nM; and 8.2 nM in HCT116, QG56, and NCI-H460 (NSCLC) cells, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TP3011 相关抗体:

Cell Proliferation Assay[2]

Cell Line: HCT116, QG56, and NCI-H460 (NSCLC) cells
Concentration: 0-100 nM
Incubation Time: 72 hours
Result: Was against human cancer cell lines, such as CRC and NSCLC cell lines.
分子量

474.51

Formula

C26H26N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TP3011 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TP3011534605-74-8CH0793011TP 3011TP-3011CH 0793011CH-0793011TopoisomeraseAOX1anti-tumorCRCNSCLCHCT116cancerInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-135845
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