2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. TZ4M

TZ4M 是一种基于 2,4-噻唑烷二酮 (TZD) 的抗阿紫海默症试剂，具有神经保护作用。TZ4M 在人血浆中表现出 AChE 抑制作用。TZ4M 在东莨菪碱 (HY-N0296) 诱导的阿尔茨海默型模型中改善成年大鼠记忆和认知障碍。

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TZ4M Chemical Structure

TZ4M Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

TZ4M 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

TZ4M is a 2,4-thiazolidinedione (TZD)-based anti-ADV agent with neuroprotective effects. TZ4M exhibits AChE inhibition in human plasma. TZ4M improves memory and cognitive impairment in adult rats in a scopolamine (HY-N0296)-induced Alzheimer-type model[1].

IC50 & Target

AChE[1]
体内研究
(In Vivo)

大鼠模型，TZ4M (2、3 mg/kg；腹腔注射；每天 1 次，共 8 天) 抑制东莨菪碱 (3 mg/kg；腹腔注射) 诱导的海马神经元损伤和海马神经元和皮质蛋白凋亡，增加海马和皮质 DG 区和 CA1 神经元中 mAChR M1 的数量[1]。
TZ4M 经 CBligand-BBB 预测为 BBB 阳性，这是 AChE 抑制所需要的[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

353.39

Formula

C19H15NO4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TZ4M 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TZ4MCholinesterase (ChE)Alzheimer's diseaseThiazolidine-2,4-dioneacetylcholinesteraseanti-Alzheimer’s agentscholinergic pathwaydementiaInhibitorinhibitorinhibit

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目录号：
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