2. Immunology/Inflammation GPCR/G Protein
  3. FLAP Leukotriene Receptor
  4. Veliflapon

Veliflapon  (Synonyms: BAY X 1005; DG-031)

目录号: HY-14165 纯度: 99.48%
COA 产品使用指南

摩尔计算器

Veliflapon (BAY X 1005; DG-031) 是一种具有口服活性的，选择性的 5-脂氧合酶激活蛋白 (FLAP) 抑制剂。Veliflapon 也是白三烯 B4 和 C4 合成的抑制剂。

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Veliflapon Chemical Structure

Veliflapon Chemical Structure

CAS No. : 128253-31-6

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3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2750
In-stock
5 mg ￥2500
In-stock
10 mg ￥4000
In-stock
25 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Veliflapon:

Veliflapon 相关抗体

Top Publications Citing Use of Products

查看 Leukotriene Receptor 亚型特异性产品:

查看所有亚型
LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Veliflapon (BAY X 1005; DG-031) is an orally active and selective 5-lipoxygenase activating protein (FLAP) inhibitor[1]. Veliflapon inhibits the synthesis of the leukotrienes B4 and C4[2].

IC50 & Target

LTB4

 

LTC4

 

体外研究
(In Vitro)

Veliflapon (BAY X 1005; DG-031) effectively inhibits the synthesis of LTB4 in A23187-stimulated leukocytes from rats, mice and humans (IC50s of 0.026, 0.039 and 0.22 μM, respectively) as well as the formation of LTC4 (IC50 of 0.021 μM) in mouse peritoneal macrophages stimulated with opsonized zymosan[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Veliflapon 相关抗体:
体内研究
(In Vivo)

Veliflapon (BAY X 1005; DG-031; diet; 18.8 mg/kg/day for 16 weeks ) inhibits atherogenesis[4].
Veliflapon after topical (18 μg/ear) and oral (48.7 mg/kg) administration has antiedematous effects in the arachidonic acid-induced mouse ear inflammation test[4].
Veliflapon is potent (11.8 and 6.7 mg/kg p.o. at 1 and 5 hours, respectively) and has a long duration of action (ED40 of 16 hours, 70 mg/kg p.o.) in the rat whole blood ex vivo leukotriene B4 inhibition assay[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female apoE/LDLR-DKO mouse model[4]
Dosage: 18.8 mg/kg
Administration: Diet; per day during 16 weeks
Result: Inhibited atherogenesis.
Clinical Trial
分子量

361.43

Formula

C23H23NO3
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (276.68 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7668 mL 13.8339 mL 27.6679 mL
5 mM 0.5534 mL 2.7668 mL 5.5336 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.48%

COA (286 KB) HNMR (133 KB) RP-HPLC (173 KB) LCMS (383 KB)

产品使用指南 (1538 KB)
参考文献

Veliflapon 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7668 mL 13.8339 mL 27.6679 mL 69.1697 mL
5 mM 0.5534 mL 2.7668 mL 5.5336 mL 13.8339 mL
10 mM 0.2767 mL 1.3834 mL 2.7668 mL 6.9170 mL
15 mM 0.1845 mL 0.9223 mL 1.8445 mL 4.6113 mL
20 mM 0.1383 mL 0.6917 mL 1.3834 mL 3.4585 mL
25 mM 0.1107 mL 0.5534 mL 1.1067 mL 2.7668 mL
30 mM 0.0922 mL 0.4611 mL 0.9223 mL 2.3057 mL
40 mM 0.0692 mL 0.3458 mL 0.6917 mL 1.7292 mL
50 mM 0.0553 mL 0.2767 mL 0.5534 mL 1.3834 mL
60 mM 0.0461 mL 0.2306 mL 0.4611 mL 1.1528 mL
80 mM 0.0346 mL 0.1729 mL 0.3458 mL 0.8646 mL
100 mM 0.0277 mL 0.1383 mL 0.2767 mL 0.6917 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Veliflapon128253-31-6BAY X 1005 DG-031BAY X1005BAY X-1005DG031DG 031DG-031FLAPLeukotriene Receptor5-lipoxygenase-activating protein5-LO activating proteinorallyactiveleukotrienesB4C45-lipoxygenaseactivatingproteinarachidonicacidmetabolismatherogenesisInhibitorinhibitorinhibit

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