2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. c-Myc PARP Apoptosis
  4. VPC-70063

VPC-70063 是一种有效的 Myc-Max 抑制剂，对 Myc-Max 转录活性抑制的 IC50 为 8.9 μM。VPC-70063 降低 UBE2C 启动子活性和 AR-V7 水平，诱导 PARP 裂解。VPC-70063 可诱导细胞凋亡 (apoptosis)，并阻断 Myc-Max 与 DNA 的相互作用。VPC-70063 可用于抗癌研究。

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VPC-70063 Chemical Structure

VPC-70063 Chemical Structure

CAS No. : 13571-44-3

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规格 价格 是否有货 数量
1 mg ￥520
In-stock
5 mg ￥1215
In-stock
10 mg ￥1750
In-stock
25 mg ￥2950
In-stock
50 mg ￥4200
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

VPC-70063 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VPC-70063 is a potent Myc-Max inhibitor with an IC50 value of 8.9 μM for Myc-Max transcriptional activity inhibition. VPC-70063 reduces UBE2C promotor activity and AR-V7 levels, and induces PARP cleavage. VPC-70063 induces apoptosis and blocks Myc-Max interactions with DNA. VPC-70063 can be used for researching anticancer[1].

IC50 & Target

IC50: 8.9 μM (Myc-Max)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
LNCaP IC50
2.5 μM
Compound: VPC-70063
Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 96 hrs by prestoblue assay
Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 96 hrs by prestoblue assay
[PMID: 30326371]
LNCaP IC50
8.9 μM
Compound: VPC-70063
Inhibition of Myc-Max (unknown origin) expressed in human LNCAP cells assessed as reduction in transcriptional activity after 1 day by luciferase reporter gene assay
Inhibition of Myc-Max (unknown origin) expressed in human LNCAP cells assessed as reduction in transcriptional activity after 1 day by luciferase reporter gene assay
[PMID: 30326371]
体外研究
(In Vitro)

VPC-70063 (25 μM; 96 h) shows Myc-Max transcriptional activity inhibition of 106% and Myc-Max/UBE2C downstream pathway inhibition of 94%[1].
VPC-70063 (6.25-25 μM, 48 h) causes apoptosis of LNCaP cells as indicated by cleavage of PARP[1].
VPC-70063 (0-500 μM; 0-600 s) disrupts the interaction of Myc-Max with DNA in a dose dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VPC-70063 相关抗体:

Western Blot Analysis[1]

Cell Line: LNCaP cells
Concentration: 6.25 μM, 12.5 μM and 25 μM
Incubation Time: 48 h
Result: Induced PARP cleavage.
分子量

378.34

Formula

C16H12F6N2S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (330.39 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6431 mL 13.2156 mL 26.4313 mL
5 mM 0.5286 mL 2.6431 mL 5.2863 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

VPC-70063 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6431 mL 13.2156 mL 26.4313 mL 66.0781 mL
5 mM 0.5286 mL 2.6431 mL 5.2863 mL 13.2156 mL
10 mM 0.2643 mL 1.3216 mL 2.6431 mL 6.6078 mL
15 mM 0.1762 mL 0.8810 mL 1.7621 mL 4.4052 mL
20 mM 0.1322 mL 0.6608 mL 1.3216 mL 3.3039 mL
25 mM 0.1057 mL 0.5286 mL 1.0573 mL 2.6431 mL
30 mM 0.0881 mL 0.4405 mL 0.8810 mL 2.2026 mL
40 mM 0.0661 mL 0.3304 mL 0.6608 mL 1.6520 mL
50 mM 0.0529 mL 0.2643 mL 0.5286 mL 1.3216 mL
60 mM 0.0441 mL 0.2203 mL 0.4405 mL 1.1013 mL
80 mM 0.0330 mL 0.1652 mL 0.3304 mL 0.8260 mL
100 mM 0.0264 mL 0.1322 mL 0.2643 mL 0.6608 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VPC-7006313571-44-3VPC70063VPC 70063c-MycPARPApoptosisMycpoly ADP ribose polymerase AnticancerAR-V7UBE2CMyc-MaxLNCaPInhibitorinhibitorinhibit

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