2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Topoisomerase Apoptosis
  4. WJ35435

WJ35435 是一种双靶向抗癌混合剂，能够诱导抗 HDAC (特别是 HDAC1 和 HDAC6) 和抗拓扑异构酶 I (topoisomerase I) 的活性，拓扑异构酶能够导致 DNA 损伤，WJ35435 具有较低的 DNA 修复能力，诱导细胞周期在 G1 和 G2 期停滞，最终导致凋亡 (apoptosis)。WJ35435 能够诱导组蛋白 H3 的乙酰化和磷酸化，α-微管蛋白的乙酰化以及 γ-H2AX 的形成，以实现抗 HDAC 的效果。WJ35435 有望用于癌症的研究。

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WJ35435 Chemical Structure

WJ35435 Chemical Structure

CAS No. : 1620054-84-3

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WJ35435 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WJ35435 is a dual-targeted anticancer hybrid that induces anti-HDAC (in particular HDAC1 and HDAC6) and anti-topoisomerase I activities that causes DNA damage associated with a low DNA repair capability and induces cell cycle arrest at G1- and G2-phase to apoptosis. WJ35435 induces histone H3 acetylation and phosphorylation, α-tubulin acetylation and γ-H2AX formation to achieve anti-HDAC effect. WJ35435 is promising for research of cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DU-145 IC50
0.16 μM
Compound: 41; WJ36435
Inhibition of colony formation in human DU-145 cells incubated for 10 days by crystal violet method
Inhibition of colony formation in human DU-145 cells incubated for 10 days by crystal violet method
[PMID: 33143937]
DU-145 IC50
0.33 nM
Compound: 15; WJ35435
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by Sulforhodamine B staining method
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by Sulforhodamine B staining method
[PMID: 33077264]
PC-3 IC50
0.31 μM
Compound: 41; WJ36435
Inhibition of colony formation in human PC-3 cells incubated for 10 days by crystal violet method
Inhibition of colony formation in human PC-3 cells incubated for 10 days by crystal violet method
[PMID: 33143937]
PC-3 IC50
0.39 nM
Compound: 15; WJ35435
Antiproliferative activity against human PC-3 cells incubated for 48 hrs by Sulforhodamine B staining method
Antiproliferative activity against human PC-3 cells incubated for 48 hrs by Sulforhodamine B staining method
[PMID: 33077264]
分子量

351.40

Formula

C20H21N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WJ35435 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WJ354351620054-84-3WJ 35435WJ-35435HDACTopoisomeraseApoptosisHistone deacetylasesanticancer hybridtopoisomerase IDNA repair capabilitycell cycle arrestapoptosishistone H3 acetylationphosphorylationα-tubulin acetylationγ-H2AX formationcancerInhibitorinhibitorinhibit

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HY-117688
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