2. Apoptosis
  3. Apoptosis
  4. Xanthoxyletin

Xanthoxyletin  (Synonyms: 花椒油素 N)

目录号: HY-N1065
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摩尔计算器

Xanthoxyletin 是一种香豆素，可以从属花椒属和黄皮属植物和中分离出来。Xanthoxyletin 具有抗氧化和抗炎活性。Xanthoxyletin 对癌细胞具有细胞毒性，并诱导凋亡和坏死。Xanthoxyletin 可用于癌症和炎症的研究。

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Xanthoxyletin Chemical Structure

Xanthoxyletin Chemical Structure

CAS No. : 84-99-1

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Xanthoxyletin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Xanthoxyletin is a coumarin that can be isolated from Genus Zanthoxylum and Clausena. Xanthoxyletin has antioxidant and anti-inflammatory activities. Xanthoxyletin shows cytotoxic effects to cancer cells, and induces apoptosis and necrosis. Xanthoxyletin can be used for the research of cancer and inflammation[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
KB IC50
133.12 μM
Compound: 8
Cytotoxicity against human KB cells by resazurin microplate assay
Cytotoxicity against human KB cells by resazurin microplate assay
[PMID: 21302964]
NCI-H187 IC50
> 200 μM
Compound: 8
Cytotoxicity against human NCI-H187 by resazurin microplate assay
Cytotoxicity against human NCI-H187 by resazurin microplate assay
[PMID: 21302964]
Vero IC50
> 200 μM
Compound: 8
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
[PMID: 21302964]
体外研究
(In Vitro)

Xanthoxyletin (1-500 µM；30 分钟) 抑制 DPPH 自由基的 IC50 值为 247.1 μM 和 63.8 μg/mL，对铁还原抗氧化能力 (FRAP) 的值为 45.2 μM[2]。
Xanthoxyletin (10-500µM；24 小时) 对 HepG2，HCT116 和 SK-LU-1 癌细胞具有细胞毒性，IC50 值分别为 78.2，79.8 和 94.4 μM[2]。
Xanthoxyletin (78 和 156 μM；12 和 24 小时) 诱导细胞凋亡，引起低坏死[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Xanthoxyletin 相关抗体:

Cell Cytotoxicity Assay[2]

Cell Line: HepG2, HCT116, SK-LU-1 and Vero cell lines
Concentration: 10-500 µM
Incubation Time: 24 hours
Result: Exhibited cytotoxicity to HepG2, HCT116 and SK-LU-1, but showed inactive effect to Vero cells.

Apoptosis Analysis[2]

Cell Line: HepG2 cell line[2]
Concentration: 78 and 156 μM
Incubation Time: 12 and 24 hours
Result: Induced apoptosis percentage of 49.6% and 64.2% at the dose of 78 and 156 μM, respectively. Showed a better apoptosis inducing effect that cisplatin.
分子量

258.27

Formula

C15H14O4
CAS 号
中文名称

花椒油素 N
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Xanthoxyletin 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Xanthoxyletin84-99-1花椒油素 NApoptosiscoumarinantioxidantanti-inflammatoryapoptosisnecrosisDPPHHepG2HCT116SK-LU-1Inhibitorinhibitorinhibit

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