2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. ZG-2305

ZG-2305 是一种有效的，选择性和具有口服活性的FIH (factor inhibiting hypoxia-inducible factor (FIH)) 抑制剂，对 FIH 和 PHD2 的 Ki 值分别为 79.6 和 2786 nM。ZG-2305 可增加 EGLN3 基因的表达。ZG-2305 可降低细胞甘油三酯水平并减少脂质积累。ZG-2305 具有研究肥胖和脂肪肝疾病的潜力。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ZG-2305 Chemical Structure

ZG-2305 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

ZG-2305 相关抗体

Top Publications Citing Use of Products

查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

查看所有亚型
HIF-1α HIF

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZG-2305 is a potent, orally active and selective factor inhibiting hypoxia-inducible factor (FIH) inhibitor with Ki values of 79.6, 2786 nM for FIH, PHD2, respectively. ZG-2305 increases the expression of EGLN3 gene. ZG-2305 decreases the cellular triglycerides levels and reduces lipid accumulation. ZG-2305 has the potential for the research of obesity and fatty liver disease[1].

IC50 & Target

Ki: 79.6 nM (FIH); 2786 nM (PHD2)[1]
体内研究
(In Vivo)

ZG-2305 能够恢复饮食诱导的肥胖雄性小鼠的异常体重和肝脏脂肪变性，并改善 HF-CDAA (胆碱缺乏的 L-氨基酸定义为高脂肪) 饮食诱导的 NASH 小鼠模型中的 NASH (非酒精性脂肪性肝炎) 相关的肝损伤、脂肪变性、炎症和纤维化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

408.19

Formula

C17H11Cl2N3O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZG-2305 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZG-2305ZG2305ZG 2305HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHHep3B cells3T3-L1 cellstriglyceridesEGLN3obesityfatty liverorally activeInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
ZG-2305
目录号：
HY-168533
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z